Results 201 to 210 of about 763,550 (239)

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarisation with K+ efflux. [PDF]

PLoS Pathog
Rojas-Palomino J, Velázquez C, Altuna-Alvarez J, González-Magaña A, Zabala-Zearreta M, Müller M, Queralt-Martín M, Alcaraz A, Albesa-Jové D.   +8 more
europepmc   +1 more source

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

Functional expression of inwardly rectifying and ATP-sensitive potassium channels in human pulmonary artery smooth muscle and endothelial cells. [PDF]

J Physiol
Barreira B, Morales-Cano D, Moreno L, de Olaiz B, Adão R, Cogolludo A, Perez-Vizcaino F, Sancho M.   +7 more
europepmc   +1 more source

Lattice Disorder in CuI Enables Filament‐Free Transparent Memristors

Advanced Science, EarlyView.
Transparent Cu1‐xAgxI thin‐film memristors rely on internal ion transport to produce reversible resistive‐switching effects. Direct elemental characterizations observe obvious Cu and Ag redistribution driven by applied bias, proving mobile ions drive the device's resistive‐switching responses.
Yuzhao Ouyang, Ke Qu, Haonan Wang, Jianquan Liu, Wei Li, Zhuoran Ji, Jialin Yang, Qiuxiang Zhu, Zhenzhong Yang, Xiaodong Tang, Hui Peng, Bobo Tian, Chungang Duan, Chang Yang   +13 more
wiley   +1 more source

Junction Physics and Architectural Paradigms in Optoelectronic Semiconductor Fibers. [PDF]

Adv Sci (Weinh)
Wang H, Ouyang W, Xiao Y, Yan W, Zhu M.
europepmc   +1 more source

Hybrid Spring‐Coupled Broadband Energy Harvester Integrated with CuSCN Functionalized Triboelectric Vibration Sensor for Self‐Sustainable Vehicular IoTs

Advanced Science, EarlyView.
A self‐sustainable vehicular vibration and indoor environment monitoring IoT platform is developed which integrates a hybrid spring‐coupled broadband energy harvester with a machine learning‐assisted PAN‐CuSCN nanofiber triboelectric vibration sensor for subtle‐to‐wide‐range vibration detection and road/speed classification.
Trilochan Bhatta, Gagan Bahadur Pradhan, Shital Sharma, MoonSeong Jo, Aklesh Teli, Hochan Chang, Jae Yeong Park   +6 more
wiley   +1 more source

Pathophysiology of homocysteine: insights into ion channel dysfunction. [PDF]

Pflugers Arch
Chmúrčiaková N, Stringer RN, Cmarko L, Filipova A, Lacinova L, Weiss N.   +5 more
europepmc   +1 more source

Exfoliated‐MoS2 Gradual Resistive Switching Devices as Artificial Synapses

Advanced Electronic Materials, EarlyView.
A vertical memristor based on untreated, exfoliated MoS2 is presented, revealing gradual resistive switching governed by Schottky barrier modulation at the MoS2/metal interface from the trapping/detrapping of charges. Furthermore, the device emulates synaptic‐like plasticity functions, including: potentiation, depression, and spike‐amplitude‐dependent ...
Deianira Fejzaj, Richard Schroedter, Thomas Mikolajick, André Heinzig   +3 more
wiley   +1 more source

Optimization of Pyrazole-Based Activators of Kv3.1. [PDF]

ACS Med Chem Lett
Spearing PK, Satpute Janve V, Romaine IM, Jayakodiarachchi N, Guttentag BW, Jana S, Kim K, Denton JS, Lindsley CW, Waterson AG.   +9 more
europepmc   +1 more source