Results 161 to 170 of about 2,418,369 (395)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

The Cumulative Incidence and Risk Factors of Recurrent Venous Thromboembolism in the Elderly

open access: yesVascular Health and Risk Management, 2020
Fahad AS Aleidan1,2 1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 2Anticoagulation Clinic, King Abdulaziz Medical City, Riyadh, Saudi ArabiaCorrespondence: Fahad AS AleidanCollege of Medicine, King ...
Aleidan FAS
doaj  

Clinical Characteristics Predict Recurrence in Borderline Ovarian Tumor Patients with Fertility-Preserving Surgery

open access: yesInternational Journal of General Medicine, 2022
Yunan He,1,* Jiaojiao Zhong,2,* Hui Yang,3 Nianchun Shan,4 Anran Cheng5,6 1Reproductive Medical Center, Department of Gynecology and Obstetrics, Tangdu Hospital, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China; 2Institute
He Y, Zhong J, Yang H, Shan N, Cheng A
doaj  

Non-recurrent parameter rays of the Mandelbrot set [PDF]

open access: yesarXiv, 2015
In this paper, we prove that any parameter ray at a non-recurrent angle $\theta$ lands at a non-recurrent parameter $c$ with $\theta$ a characteristic angle of $f_c$; and conversely, every non-recurrent parameter $c$ is the landing point of one or two parameter rays at non-recurrent angles, and these angles are exactly the characteristic angles of $f_c$
arxiv  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Kronecker Recurrent Units [PDF]

open access: yesarXiv, 2017
Our work addresses two important issues with recurrent neural networks: (1) they are over-parameterized, and (2) the recurrence matrix is ill-conditioned. The former increases the sample complexity of learning and the training time. The latter causes the vanishing and exploding gradient problem.
arxiv  

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

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