Results 31 to 40 of about 972,358 (268)

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Landscape analysis of m5C modification regulators unveils DNMT1-mediated dysregulated pyrimidine metabolism in hepatocellular carcinoma

Clinical Epigenetics
The 5-methylcytosine (m5C) post-transcriptional modification has been linked with the development and progression of a variety of cancers. However, its specific functions and their underlying mechanisms are poorly understood in hepatocellular carcinoma ...
Xuhui Zhao, Shengwei Mao, Yuan Fang, Jiafeng Chen, Lifu Bi, Jie Li, Jinglei Wu, Jun Gao, Shiguang Yang, Jialu Fu, Xiaoling Wu, Guiqi Zhu, Zheng Tang, Yinghong Shi, Jian Zhou, Jia Fan, Xingxing Zhang, Jinling Jiang, Weiren Liu   +18 more
doaj   +1 more source

GULP1 as a novel diagnostic and predictive biomarker in hepatocellular carcinoma [PDF]

Clinical and Molecular Hepatology
Background/Aims Hepatocellular carcinoma (HCC) is characterized by high recurrence and mortality, necessitating the identification of reliable biomarkers.
Hyung Seok Kim, Jung Hwan Yoon, Ji Yi Choi, Moon Gyeong Yoon, Geum Ok Baek, Minji Kang, Se Ha Jang, Won Park, Yunjin Go, Jestlin Tianthing Ng, Suk Woo Nam, Jee-Yeong Jeong, Ji Eun Han, Hyo Jung Cho, Su Bin Lim, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +17 more
doaj   +1 more source

circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR‐520c‐3p/methyl‐DNA‐binding domain protein 2 axis

Clinical and Translational Medicine, 2022
Background Recurrence is the major cause of hepatocellular carcinoma (HCC) death. We aimed to identify circular RNA (circRNA) with predictive and therapeutic value for recurrent HCC.
Donghong Liu, Wenbin Liu, Xi Chen, Jianhua Yin, Longteng Ma, Mei Liu, Xinyu Zhou, Linfeng Xian, Peng Li, Xiaojie Tan, Jun Zhao, Yong Liao, Guangwen Cao   +12 more
doaj   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Navigating the complexity of current interventional radiological approaches for distant metastases in thyroid cancer

Frontiers in Endocrinology
The finding of liver metastases in thyroid cancer is relatively uncommon. Treatment is complex and depends on several factors, including location, number and size of lesions, associated symptoms, extrahepatic disease and patient’s condition.
Daqi Zhang, Jerry Spisani, Arianna Ceriello, Francesco Frattini, Francesco Brucchi, Francesco Brucchi, Gianlorenzo Dionigi, Gianlorenzo Dionigi, Lanlan Wan, Alessio Salvatore Angileri, Carla Colombo, Carla Colombo, Anna Maria Ierardi, Gianpaolo Carrafiello   +13 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Prevalence of Smoking Among Spontaneous Pneumothorax Patients and Its Impact on Treatment in Syria Country: A Cross‐Sectional Study

Health Science Reports
Background and Aims Spontaneous Pneumothorax (SP) is a case where air is collected in the pleural space, with smoking recognized as a major risk factor. Despite the global burden of SP, there is limited research on its prevalence and recurrence in Middle
Muhanad Munzer, Nafiza Martini, Mhd Mustafa Albitar, Lilas Channiss, Mohammed Martini, Hussam Al bardan   +5 more
doaj   +1 more source