Results 151 to 160 of about 3,946,822 (379)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Geometrical Interpretation of the Master Theorem for Divide-and-conquer Recurrences [PDF]

open access: yesarXiv, 2009
We provide geometrical interpretation of the Master Theorem to solve divide-and-conquer recurrences. We show how different cases of the recurrences correspond to different kinds of fractal images. Fractal dimension and Hausdorff measure are shown to be closely related to the solution of such recurrences.
arxiv  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Binomial sums about Bernoulli, Euler and Hermite polynomials [PDF]

open access: yesDiscrete Mathematics Letters, 2020
Xiaoyuan Wang, Wenchang Chu
doaj   +1 more source

Generalized Horadam Polynomials and Numbers

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2018
We consider the polynomials hn,m(x) (m ≥ 2) and the numbers hn,m (x = 1), which are the generalized Horadam polynomials and the generalized Horadam numbers, respectively. We also consider the polynomials h(s)n,m(x)- convolutions of the polynomials hn,m(x)
Djordjevic Snezana S.   +1 more
doaj   +1 more source

Recurrence relations for degenerate Bell and Dowling polynomials via Boson operators [PDF]

open access: yesarXiv
Spivey found a recurrence relation for the Bell numbers by using combinatorial method. The aim of this paper is to derive Spivey's type recurrence relations for the degenerate Bell polynomials and the degenerate Dowling polynomials by using the boson annihilation and creation operators satisfying the commutation relation aa+-a+a=1.
arxiv  

Principal solutions of recurrence relations and irrationality questions in number theory [PDF]

open access: yesarXiv, 2006
We apply the theory of disconjugate linear recurrence relations to the study of irrational quantities in number theory. In particular, for an irrational number associated with solutions of three-term linear recurrence relations we show that there exists a four-term linear recurrence relation whose solutions allow us to show that the number is a ...
arxiv  

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

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