Results 111 to 120 of about 3,225,031 (302)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Corrigendum: The role of NR4A1 in the pathophysiology of osteosarcoma: A comprehensive bioinformatics analysis of the single-cell RNA sequencing dataset

Frontiers in Oncology, 2022
Weidong Liu, Yuedong Hao, Xiao Tian, Jing Jiang, Quanhe Qiu   +4 more
doaj   +1 more source

Repeated annual influenza vaccination and vaccine effectiveness: review of evidence

Expert Review of Vaccines, 2017
Introduction: Studies in the 1970s and 1980s signaled concern that repeated influenza vaccination could affect vaccine protection. The antigenic distance hypothesis provided a theoretical framework to explain variability in repeat vaccination effects ...
Edward A. Belongia, Danuta M. Skowronski, Huong Q. McLean, Catharine Chambers, Maria E. Sundaram, Gaston De Serres   +5 more
doaj   +1 more source

The Role of Cortico-Thalamo-Cortical Circuits in Language: Recurrent Circuits Revisited [PDF]

, 2019
Bruce Crosson
openalex   +1 more source

Effect of triptolide and chemotherapy on carcinoembryonic and carbohydrate antigens levels and first-line treatment of recurrent nasopharyngeal carcinoma

, 2021
Cui Liu, Xiaolin Yuan, Xiaobo Liu, Kuai Liang, Zhigang Ni, Gaoxin Yu, Li Zhu   +6 more
openalex   +2 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Toward Abstraction from Multi-modal Data: Empirical Studies on Multiple Time-scale Recurrent Models

, 2017
The abstraction tasks are challenging for multi- modal sequences as they require a deeper semantic understanding and a novel text generation for the data. Although the recurrent neural networks (RNN) can be used to model the context of the time-sequences,
Cangelosi, Angelo, Ogata, Tetsuya, Zhong, Junpei   +2 more
core  

An umbrella study of biomarker-driven targeted therapy in patients with platinum-resistant recurrent ovarian cancer: a Korean Gynecologic Oncology Group study (KGOG 3045), AMBITION [PDF]

, 2019
Jung‐Yun Lee, Ju Yeon Yi, Hyun Soo Kim, June Lim, Sunghoon Kim, Byoung Ho Nam, Hee Seung Kim, Jae‐Weon Kim, Chel Hun Choi, Byoung‐Gie Kim   +9 more
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Integrated Community-Based Care for Dependent Older People Community Participation in Preparation for Recurrent Outbreaks of COVID-19

Journal of Multidisciplinary Healthcare
Supichaya Wangpitipanit,1 Sangduen Piyatrakul,1 Thida Tongvichean2 1Division of Community Health Nursing, Ramathibodi School of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Faculty of Nursing, Shinawatra ...
Wangpitipanit S, Piyatrakul S, Tongvichean T   +2 more
doaj