Results 81 to 90 of about 3,225,031 (302)

Optical Coherence Tomography Angiography Findings in Ocular Toxoplasmosis with Multiple Recurrences

International Medical Case Reports Journal, 2023
Ovi Sofia,1,2 I Nyoman Surya Ari Wahyudi,3 Loeki Enggar Fitri,4 Seskoati Prayitnaningsih,2 Hani Susianti5 1Doctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; 2Department of Ophthalmology, Faculty of ...
Sofia O, Wahyudi INSA, Fitri LE, Prayitnaningsih S, Susianti H   +4 more
doaj  

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Relationship between levels of novel inflammatory indicators and aggressivity in patients with first-episode and recurrent schizophrenia

Sichuan jingshen weisheng
BackgroundAggressive behavior in schizophrenic patients could result in legal disputes and public safety concerns. In patients with illness episodes of different numbers， there may exist differences in the association between levels of novel inflammatory
Cui Ying'ao, Yang Cheng, Tian Yinghan, Shen Qingqing, Liu Huanzhong   +4 more
doaj   +1 more source

Phase 1 Study Evaluating the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib and Cetuximab in Recurrent/Metastatic p16-Negative Squamous Cell Carcinoma of the Head and Neck

Frontiers in Oncology, 2019
Background: The majority of human papillomavirus (HPV)-negative squamous cell carcinoma of the head and neck (SCCHN) present upregulation of the epidermal growth factor receptor (EGFR) and frequent alterations in the cyclin D1-cyclin dependent kinase ...
Emmanuel Seront, Emmanuel Seront, Sandra Schmitz, Matthias Papier, Aline van Maanen, Stéphanie Henry, Christophe Lonchay, Sylvie Rottey, Gabrielle van Caloen, Jean-Pascal Machiels   +9 more
doaj   +1 more source

Simple Recurrent Units for Highly Parallelizable Recurrence

, 2018
Common recurrent neural architectures scale poorly due to the intrinsic difficulty in parallelizing their state computations. In this work, we propose the Simple Recurrent Unit (SRU), a light recurrent unit that balances model capacity and scalability ...
Artzi, Yoav, Dai, Hui, Lei, Tao, Wang, Sida I., Zhang, Yu   +4 more
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Tubularized incised plate and onlay island flap urethroplasty for management of fresh and recurrent hypospadias repair

Al-Azhar Assiut Medical Journal
Background and aim Hypospadias is the most prevalent congenital abnormality of the male genitalia, recurrent hypospadias is a term referrer to patients who have undergone unsuccessful attempts for hypospadias repair due to complications, and the proper ...
Mohamed M.A.A. Hamid, Hazem A.S. Deif, Emadeldeen S.A. Saleh, Mahmoud I.A.A. Baqi   +3 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Evaluation of periosteal fixation of lateral rectus and partial VRT for cases of exotropic Duane retraction syndrome

Indian Journal of Ophthalmology, 2014
Purpose: The purpose of this study is to evaluate the lateral rectus periosteal fixation and partial vertical rectus transpositioning (VRT) as treatment modalities to correct exotropic Duane retraction syndrome (Exo-DRS).
Pradeep Sharma, Ruchi Tomer, Vimla Menon, Rohit Saxena, Anudeepa Sharma   +4 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source