Results 91 to 100 of about 585,882 (283)
Frontiers in Cellular Neuroscience, 2019 Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel implicated in the nervous system as a key component of several inflammatory diseases. A massive amount of evidence has demonstrated that TRPV1 is extensively expressed
Weilin Kong +8 more
doaj +1 more source
Endogenous neuropeptide Y prevents recurrence of experimental febrile seizures by increasing seizure threshold [PDF]
, 2005 Febrile seizures (FSs) typically occur at the onset of fever and do not recur within the same febrile episode despite enduring or increased hyperthermia.
Gonzalez-Vega, Rebeca +4 more
core +1 more source
Climate‐related exposures and seizures in children: A systematic review
Epilepsia, EarlyView.Abstract Objective Climate‐related exposures, including air pollution, temperature extremes, humidity, and atmospheric conditions, are increasingly recognized as potential seizure triggers. As climate change intensifies, understanding the environmental contributors to pediatric seizure risk has important implications for anticipatory guidance and ...
Caroline Sarpy +5 more
wiley +1 more source
Epilepsia, EarlyView.Abstract The classification of the epilepsies has traditionally relied on clinical and electroencephalographic features. However, advancements in molecular genetics, neuroimaging, and our understanding of epilepsy pathophysiology necessitate a shift toward an etiology‐based approach.
Nicola Specchio +15 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective In temporal lobe epilepsy (TLE), patients often present with neurobehavioral comorbidities encompassing affective and cognitive difficulties. Whereas the latter have been related to atypical connectivity of mesiotemporal and frontotemporal circuits, the brain basis of affective symptoms remains incompletely understood.
Fatemeh Fadaie +4 more
wiley +1 more source
Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome
Annals of Clinical and Translational Neurology, 2019 De novo loss‐of‐function mutations in SCN1A are the main cause of Dravet syndrome, a catastrophic encephalopathy characterized by recurrent early‐life febrile seizures, a number of other afebrile seizure types that are often refractory to treatment, and ...
Jennifer C. Wong +2 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Levetiracetam (LEV) is an antiseizure medication approved for focal and generalized epilepsy. Despite its efficacy, neuropsychiatric adverse effects (NP‐AEs) may lead to treatment discontinuation. Quantitative electroencephalographic (qEEG) graph‐theoretical analysis has emerged as a valuable tool for identifying neurophysiological ...
Marco Sferruzzi +10 more
wiley +1 more source
Functional profiling of STXBP1 missense variants using a novel dual‐readout fluorometric assay
Epilepsia, EarlyView.Abstract Objective STXBP1‐related disorders (STXBP1‐RD) are among the most common genetic neurodevelopmental disorders, marked by early onset epilepsy, global developmental delay, and motor impairments. Many missense variants remain uncharacterized, limiting accurate variant interpretation and hindering development of precision therapies.
Elisa A. Waxman +11 more
wiley +1 more source
Asian Journal of Medical SciencesBackground: Febrile seizures are common in children under five, with simple seizures being brief and harmless, while complex seizures have higher risks.
Mahalakshmi P +3 more
doaj +1 more source