Results 51 to 60 of about 349,230 (288)

Compressing Recurrent Neural Network with Tensor Train

open access: yes, 2017
Recurrent Neural Network (RNN) are a popular choice for modeling temporal and sequential tasks and achieve many state-of-the-art performance on various complex problems.
Nakamura, Satoshi   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Modelling Identity Rules with Neural Networks [PDF]

open access: yes, 2019
In this paper, we show that standard feed-forward and recurrent neural networks fail to learn abstract patterns based on identity rules. We propose Repetition Based Pattern (RBP) extensions to neural network structures that solve this problem ...
Kopparti, R. M., Weyde, T.
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Micrometer Backstepping Control System for Linear Motion Single Axis Robot Machine Drive

open access: yesSensors, 2019
In order to cut down influence on the uncertainty disturbances of a linear motion single axis robot machine, such as the external load force, the cogging force, the column friction force, the Stribeck force, and the parameters variations, the micrometer ...
Chih-Hong Lin, Kuo-Tsai Chang
doaj   +1 more source

Ridge Polynomial Neural Network with Error Feedback for Time Series Forecasting. [PDF]

open access: yesPLoS ONE, 2016
Time series forecasting has gained much attention due to its many practical applications. Higher-order neural network with recurrent feedback is a powerful technique that has been used successfully for time series forecasting.
Waddah Waheeb   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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