Results 51 to 60 of about 354,413 (309)

Estimation of applicability of modern neural network methods for preventing cyberthreats to self-organizing network infrastructures of digital economy platformsa,b

SHS Web of Conferences, 2018
The problems of applying neural network methods for solving problems of preventing cyberthreats to flexible self-organizing network infrastructures of digital economy platforms: vehicle adhoc networks, wireless sensor networks, industrial IoT, “smart ...
Kalinin Maxim, Krundyshev Vasiliy, Zubkov Evgeny   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Adverse Drug Reaction Classification With Deep Neural Networks [PDF]

, 2016
We study the problem of detecting sentences describing adverse drug reactions (ADRs) and frame the problem as binary classification. We investigate different neural network (NN) architectures for ADR classification.
He, Yulan, Huynh, Trung, Rüger, Stefan, Willis, Alistair   +3 more
core   +1 more source

Scaling Recurrent Neural Network Language Models

, 2015
This paper investigates the scaling properties of Recurrent Neural Network Language Models (RNNLMs). We discuss how to train very large RNNs on GPUs and address the questions of how RNNLMs scale with respect to model size, training-set size ...
Ash, Tom, Mrva, David, Prasad, Niranjani, Robinson, Tony, Williams, Will   +4 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Bidirectional convolutional recurrent neural network architecture with group-wise enhancement mechanism for text sentiment classification

Journal of King Saud University: Computer and Information Sciences, 2022
Sentiment analysis has been a well-studied research direction in computational linguistics. Deep neural network models, including convolutional neural networks (CNN) and recurrent neural networks (RNN), yield promising results on text classification ...
Aytuğ Onan
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Micrometer Backstepping Control System for Linear Motion Single Axis Robot Machine Drive

Sensors, 2019
In order to cut down influence on the uncertainty disturbances of a linear motion single axis robot machine, such as the external load force, the cogging force, the column friction force, the Stribeck force, and the parameters variations, the micrometer ...
Chih-Hong Lin, Kuo-Tsai Chang
doaj   +1 more source

Learning Spectral-Spatial-Temporal Features via a Recurrent Convolutional Neural Network for Change Detection in Multispectral Imagery

, 2018
Change detection is one of the central problems in earth observation and was extensively investigated over recent decades. In this paper, we propose a novel recurrent convolutional neural network (ReCNN) architecture, which is trained to learn a joint ...
Bruzzone, Lorenzo, Mou, Lichao, Zhu, Xiao Xiang   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source