Results 61 to 70 of about 312,321 (283)
JuTISI (Jurnal Teknik Informatika dan Sistem Informasi), 2020 Nowadays internet access is getting easier to get. Because of the ease of access to the internet, almost all internet users have social media. Social media is widely used by users to call out their opinions or even to make complaints about a matter and ...
Ivan Nathaniel Husada, Hapnes Toba
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Discontinuities in recurrent neural networks [PDF]
, 1997 This paper studies the computational power of various discontinuous real computational models that are based on the classical analog recurrent neural network (ARNN).
Gavaldà Mestre, Ricard +1 more
core +1 more source
PredictPTB: An Interpretable Preterm Birth Prediction Model Using Attention-based Recurrent Neural Networks [PDF]
, 2021 Rawan AlSaad +2 more
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hierarchical Temporal Representation in Linear Reservoir Computing
, 2017 Recently, studies on deep Reservoir Computing (RC) highlighted the role of layering in deep recurrent neural networks (RNNs). In this paper, the use of linear recurrent units allows us to bring more evidence on the intrinsic hierarchical temporal ...
Claudio Gallicchio +12 more
core +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
The Power of Linear Recurrent Neural Networks
, 2020 Recurrent neural networks are a powerful means to cope with time series. We show how a type of linearly activated recurrent neural networks, which we call predictive neural networks, can approximate any time-dependent function f(t) given by a number of ...
Litz, Sandra +3 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source