Results 121 to 130 of about 256,448 (384)

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

Comparison of Ankle Proprioception Between Pregnant and Non Pregnant Women [PDF]

, 2011
Pregnant women report falls especially during their third trimester. Physiological changes along with ligament laxity can affect the joint proprioception in this population.
R, Preetha, SM, John
core   +1 more source

Trial protocol OPPTIMUM : does progesterone prophylaxis for the prevention of preterm labour improve outcome? [PDF]

, 2012
Background Preterm birth is a global problem, with a prevalence of 8 to 12% depending on location. Several large trials and systematic reviews have shown progestogens to be effective in preventing or delaying preterm birth in selected high risk women ...
A Shennan, American College of Obstetricians and Gynecologists, Andrew Shennan, Anon, AT Northen, BAPM/RCPCH Working Group Report, D Farine, D Wolke, EB da Fonseca, EB Fonseca, H Honest, IR Edwards, Jane E Norman, JE Norman, JM Dodd, JM Dodd, John Norrie, L Sanchez-Ramos, M Arbyn, M Junpeng, March of Dimes Foundation, N Modi, Neil Marlow, Neil Sebire, PA Lachenbruch, Phillip Bennett, PJ Meis, R Romero, RL Goldenberg, RN Hoover, S Kenyon, SL Kenyon, Sonia Whyte, SS Hassan, Stavros Petrou, Stephen Robson, Steven Thornton, Tina Lavender   +37 more
core   +4 more sources

Association of reduced maternal sHLA‐G5 isoform levels and elevated TNF‐α/IL‐4 cytokine ratio with Recurrent Pregnancy Loss: A study on South Indian women [PDF]

, 2021
Dhatri Madduru, Kethora Dirsipam, Mahalakshmi Goli, Venkata Ramana Devi, Parveen Jahan   +4 more
openalex   +1 more source

Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release

Advanced Science, EarlyView.
The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu   +17 more
wiley   +1 more source

Author's reply – Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses: A double-blind, randomised, placebo-controlled trial

EClinicalMedicine, 2022
Hideto Yamada, Masashi Deguchi, Shigeru Saito, Toshiyuki Takeshita   +3 more
doaj   +1 more source

Familly with two different cases of post- and pre-natal L1 syndrome; When hydrocephaly become "multidisciplinary headache" [PDF]

, 2016
open11openBukvic, Nenad; Boaretto, Francesca; Loverro, Giuseppe; Susca, Francesco C.; Lovaglio, Rosaura; Patruno, Margherita; Bukvic, Dragoslav; Starcevic, Srdjan; Vazza, Giovanni; Mostaciuollo, Maria Luisa; Resta, NicolettaBukvic, Nenad; Boaretto ...
Boaretto, Francesca, Bukvic, Dragoslav, Bukvic, Nenad, Lovaglio, Rosaura, Loverro, Giuseppe, Mostaciuollo, Maria Luisa, Patruno, Margherita, Resta, Nicoletta, Starcevic, Srdjan, Susca, Francesco C., Vazza, Giovanni   +10 more
core   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report

Thrombosis Journal, 2007
Background Hyperhomocysteinemia has been described as a risk factor for unexplained recurrent pregnancy loss. Increased levels of homocysteine may be due to inadequate dietary intake of folate and vitamin B12 and inherited defects within the methionine ...
Mollo Antonio, Ranieri Antonio, Iannuzzo Mariateresa, Alviggi Carlo, Di Micco Pierpaolo, Strina Ida, D'Uva Maristella, De Placido Giuseppe   +7 more
doaj   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source