Results 281 to 290 of about 234,611 (389)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk   +4 more
wiley   +1 more source

Risk factors associated with pregnancy outcomes in patients with recurrent pregnancy loss after treatment. [PDF]

open access: yesBMC Pregnancy Childbirth
Fang T   +9 more
europepmc   +1 more source

Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies. [PDF]

open access: yesInt J Gynaecol Obstet
Yang T   +11 more
europepmc   +1 more source

Efficacy of phenobarbital is maintained after exposure to mild‐to‐moderate seizures in neonates

open access: yesEpilepsia Open, EarlyView.
Abstract To study the relationship between the delay in treatment and the efficacy of phenobarbital in neonates, we re‐analyzed data from the NEOLEV2 study. Continuous video EEG (cEEG) from patients treated with phenobarbital was reviewed by neurophysiologists who marked each seizure.
Cynthia Sharpe   +9 more
wiley   +1 more source

Maternal-Fetal Compatibility in Recurrent Pregnancy Loss. [PDF]

open access: yesJ Clin Med
Cuadrado-Torroglosa I   +2 more
europepmc   +1 more source

Sperm DNA fragmentation and recurrent pregnancy loss: a systematic review and meta-analysis.

open access: yesFertility and Sterility, 2019
D. McQueen, John Z. H. Zhang, J. Robins
semanticscholar   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

open access: yesEpilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola   +3 more
wiley   +1 more source

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