Results 141 to 150 of about 2,358,294 (308)

Azithromycin for Recurrent Respiratory Tract Infections in Pediatric Populations [PDF]

, 2016
Background: Severe lower respiratory tract infections in pediatric populations result in millions of hospitalizations worldwide. Some children experience recurrent symptoms and progressive episodes multiple times a year. Azithromycin has demonstrated not
Pino, Mikala Guadalupe
core  

Algorithm for the selection of therapy for bacterial infection of the upper respiratory tract in children

Медицинский совет, 2015
Respiratory diseases occupy first place in the total list of diseases in the world; the incidence of respiratory diseases in adults is 27.6%, in adolescents - 39.9% and in children - 61% [1], thus making the problem a matter of undying interest in ...
N. L. Kunelskaya, A. Y. Ivoylov, M. I. Kulagina   +2 more
doaj   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Human Metapneumovirus Infection in a Patient with Recurrent Wheezing: Case Report

İstanbul Medical Journal, 2019
Lower respiratory tract infections are responsible for 28% of preventable and treatable childhood deaths under 2 years of age in the world. In recent years, due to advances on the factors of respiratory tract infections, new agents such as human ...
Öner Özdemir, Onur Bircan
doaj   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Incidence of respiratory tract infections and antibiotic use in primary health care [PDF]

, 2016
Background . Respiratory tract infections are of viral etiology in around 70% of cases. The most popular treatment method is the empirical approach based on a medical interview and a physical examination, using the doctor’s personal experience.
Małgorzata Pietrzykowska, Janusz Siebert, Siebert, Janusz, Katarzyna Nowicka-Sauer, Nowicka-Sauer, Katarzyna, Gutknecht, Piotr, Pietrzykowska, Małgorzata, Piotr Gutknecht   +7 more
core   +2 more sources

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

Management of respiratory tract infections in children

, 2014
Siba Prosad Paul,1 Rachel Wilkinson,2 Christine Routley3 1Southmead Hospital, Bristol, 2St Richard's Hospital, Chichester, 3Paediatric Services, Yeovil District Hospital, Yeovil, UK Abstract: Respiratory tract infections (RTIs) in children are one ...
Routley C, Wilkinson R, Paul SP
core  

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source