Results 241 to 250 of about 107,979 (335)

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

open access: yesAdvanced Materials, Volume 38, Issue 17, 20 March 2026.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu   +15 more
wiley   +1 more source

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li   +12 more
wiley   +1 more source

A Novel Contact‐Implicit Trajectory Optimization Framework for Quadruped Locomotion without Fixed Contact Sequences

open access: yesAdvanced Intelligent Systems, Volume 8, Issue 3, March 2026.
Legged robots have advanced in environmental interaction through contact, but most works rely on fixed contact sequences. This work presents a new method based on an indirect optimization method for legged robots to automatically generate contact sequences for complex movements.
Yaowei Chen, Jie Zhang, Ming Lyu
wiley   +1 more source

Degeneracy Sensing Light Detection and Ranging‐Inertial Simultaneous Localization and Mapping with Dual‐Layer Resistant Odometry and Scan‐Context Loop‐Closure Detection Backend in Diverse Environments

open access: yesAdvanced Intelligent Systems, Volume 8, Issue 3, March 2026.
This paper presents a degeneracy‐aware light detection and ranging (LiDAR)‐inertial framework that enhances LiDAR simultaneous localization and mapping performance in challenging environments. The proposed system integrates a dual‐layer robust odometry frontend with a Scan‐Context‐based loop‐closure detection backend.
Haoming Yang   +4 more
wiley   +1 more source

Contact Force Estimation of Continuum Robots without Embedded Sensors: A Review

open access: yesAdvanced Intelligent Systems, Volume 8, Issue 3, March 2026.
This review surveys methods for estimating contact forces in continuum robots without embedded sensors. It explains why contact force matters, classifies force patterns, and groups existing methods into three approaches based on actuation, deformation, and environment information.
An Hu, Yu Sun
wiley   +1 more source

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