Results 61 to 70 of about 53,952 (260)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Recyclable fire-retardant bio-based thermosets: From molecular engineering to performances and applications [PDF]
Thermosets play a critical role in aerospace, automotive, electronics, and construction industries due to their mechanical strength, thermal stability, and chemical resistance.
Yang, Qingshan +7 more
core +1 more source
Hive-inspired nano-carriers for recyclable single-chain nano-catalysts
Nano ResearchMetal catalysts supported by single-chain nanoparticles (SCNPs) can exhibit high efficiency and selectivity due to excellent dispersibility in solution and nanoconfinement effects.
Zhiyu Hu, Yangjing Chen, Hongting Pu
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
, 2011 Recyclable Enamine Catalysts for Asymmetric Direct Cross-aldol Reaction of Aldehydes in Emulsion MediaHighly diastereo- and enantioselective cross-aldol reactions of aldehydes (> 20 : 1 dr, 99% ee), catalyzed by chiral diamine-polyoxometalate acid ...
Liu, Yan +10 more
core +1 more source
Chimica Techno ActaVariously substituted methylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) derivatives were synthesized in 83–96% yield by the reaction of substituted benzaldehyde with 5, 5-dimethyl-1, 3-cyclohexanedione in the presence of CuO nanoparticles (NPs ...
Ravina Meena, Harshita Sachdeva
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Green Chemistry Letters and ReviewsIron is the most abundant transition metal on Earth. In this study, we have demonstrated an iron nanoparticle–loaded kaolin-catalyzed cross dehydrogenative coupling (CDC) reaction via C(sp3)–H activation.
Dao Su +3 more
doaj +1 more source