Results 41 to 50 of about 1,257,653 (311)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Construction and Building Materials, 2019 This study introduced both steel slag and recycled aggregate aiming to improve the sustainability performance of self-compacting concrete (SCC). The study focused on investigating the effects of steel slag powder on the properties of self-compacting ...
Z. Pan +10 more
semanticscholar +1 more source
, 2020 Durability is a major concern in concrete (particularly recycled concrete) structures exposed to carbonation-induced corrosion, given the social, economic, environmental and safety implications involved.
I. F. S. D. Bosque +4 more
semanticscholar +1 more source
Structural Performance of Recycled Aggregate Concrete Confined by Spiral Reinforcement
Journal of Asian Architecture and Building Engineering, 2018 This paper estimates the structural behavior of recycled aggregate concrete confined by spiral reinforcement. The main test parameters are designed to be the type of aggregates, replacement ratio of recycled aggregates, steel ratio and yield strength of ...
Sang-Woo Kim +4 more
doaj +1 more source
Mehran University Research Journal of Engineering and Technology, 2021 The energy dissipation capacity of concrete is an important aspect for a Reinforced Concrete (RC) structure to be seismically resistant. Various types of concrete incorporating sustainable materials are being developed these days such as recycled ...
Muhammad Rizwan Riaz +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Materials, 2019 Today, the use of recycled aggregates as a substitute for a part of the natural aggregates in concrete production is increasing. This approach is essential because the resources for natural aggregates are decreasing in the world.
M. Nili, Hossein Sasanipour, F. Aslani
semanticscholar +1 more source
Buildings, 2020 The main objective of this paper is to provide the industry with a simple and practical way of disposing and recovering recycled waste from precast reinforced concrete elements rejected during the quality control process, while minimizing the consumption
Tiago Barroqueiro +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source