Results 51 to 60 of about 243,504 (265)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Recycling Paper Recycling

BioResources, 2014
What do you do after a product has served its function and is no longer needed? Ideally, you recycle it. What do you do if people have neglected or forgotten so much of what has been learned in recent years about paper recycling? Well, one of the things that someone can do is to write a book. Very little of the contents of such a book may be new.
openaire   +3 more sources

Assessing Surface Topographies of 3D-Printed Polymer Tooling: Implications for Enhanced Injection Moulding Performance

Advances in Polymer Technology
Injection moulding (IM) is a precise manufacturing process capable of producing tight-tolerance, functional plastic components with high-quality surface finishes.
Gavin Keane, Guangming Yan, Billy Shu Hieng Tie, Alan Mannion, Andrew V. Healy, Declan M. Devine   +5 more
doaj   +1 more source

Migration of CO2 in Porous Media Filled with water.

Journal of Thermal Science and Technology, 2006
This paper describes experimental research on two-phase flow of supercritical carbon dioxide (CO2) and water in porous media under sequestration conditions.
Tetsuya SUEKANE, Toshihiro ISHII, Shoji TSUSHIMA, Shuichiro HIRAI   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pretreatment Process of Polymetallic Complex Copper Anode Slime by Oxygen Pressure Acid Leaching

Kuangchan zonghe liyong
The removal of copper and nickel from complex copper anode slime by oxygen pressure acid leaching was studied. The effects of reaction temperature, sulfuric acid concentration, liquid-solid ratio, stirring speed, oxygen partial pressure and reaction time
Jun LI, Zhaoan ZHOU, Xiaowen LIU, Yanjun SUN, Guohong XU, Anzhang MAO, Aiqing ZHOU   +6 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Preparation of Black Copper Electrolyte by Acid Oxidation Leaching of Refining Slag

Kuangchan zonghe liyong
This is an article in the field of metallurgical engineering. The preparation of black copper electrolyte by removing copper from secondary refining slag of high copper and high tin anode furnace by hydrogen peroxide oxidation and acid leaching was ...
Jun LI, Zhaoan ZHOU, Xiaowen LIU, Anzhang MAO, Yanjun SUN, Aiqing ZHOU   +5 more
doaj   +1 more source