Results 161 to 170 of about 4,409,042 (310)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Australian Red Cross Annual Report

open access: yes, 2001
This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete.
Australian Red Cross Society, National Office
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Space-Time-Frequency Shift Keying for Dispersive Channels

open access: yes, 2011
Inspired by the concept of the Space-Time Shift Keying (STSK) modulation, in this paper we proposed the Space-Frequency Shift Keying (SFSK) modulation as well as the Space-Time-Frequency Shift Keying (STFSK) concept which spreads the transmit signal not ...
Sugiura, Shinya   +3 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

The Red Shift in Estrogen Research: An Estrogen-Receptor Targeted <i>aza</i>-BODIPY-Estradiol Fluorescent Conjugate. [PDF]

open access: yesInt J Mol Sci
Hlogyik T   +13 more
europepmc   +1 more source

Language Shift

open access: yes, 2012
This research is intended to ascertain the factors that are responsible for banishing Punjabi language and a corresponding adoption of English language though apparently the panoramic milieu is hostile to this shift Language shift is a societal trend ...
anayakhan35, Muhammad Ramzan
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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