Results 131 to 140 of about 11,378,899 (295)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Revista Iberoamericana de Educación, 2012 Los docentes son el centro de los sistemas educativos de calidad. Todo sistema educativo que pretenda alcanzar importantes indicadores de calidad, debe procurar procesos de formación de sus docentes.
Maria Angélica Múnera Soto +1 more
doaj
Medicaid-the need for reform [PDF]
Recent administration proposals to address the rising cost of Medicaid will do little to contain costs or truly reform the program. The primary issues are the large differences among state Medicaid programs in coverage and benefits and the programs high ...
Alan Weil, John Holahan
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Revista de Biología Tropical, 2013 La langosta verde Panulirus gracilis es un recurso de gran importancia económica para las poblaciones pesqueras de la costa continental del Ecuador. Esta especie es capturada tradicionalmente mediante redes y buceo semiautónomo (hookah).
Juan Figueroa, David Mero
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How well are the states of the Eighth Federal Reserve District prepared for the next recession? [PDF]
Economic downturns often force state policymakers to enact sizable tax increases or spending cuts to close budget shortfalls. In this paper the authors make use of a Markov-switching regression model to empirically describe the expansions and ...
Erick Elder, Gary A. Wagner
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Educar y aprender en la sociedad-red
Revista del CISEN, 2013 "Crisis" es uno de los términos que más frecuentemente escuchamos en los discursos referidos a la educación. Está sensación de inquietud, dificultad e incertidumbre está relacionada con los cambios vertiginosos que estamos viviendo.
Denise Najmanovich
doaj