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Red‐blood‐cell alloimmunization and number of red‐blood‐cell transfusions
Vox Sanguinis, 2011Background Patients receiving red‐blood‐cells may form antibodies against the alloantigens expressed by red‐blood‐cells, with the risk of serious morbidity and the need for extensive phenotype‐matching in subsequent transfusions. The incidence of alloimmunization is considered variable for specific patient groups and for first time antibody formation.
Zalpuri, S. +5 more
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Red Blood Cell ATP Release Correlates with Red Blood Cell Hemolysis
The FASEB Journal, 2017The elegant and precise matching of blood flow to skeletal muscle from the onset of exercise through the steady state remains an important area of investigation. Release of adenosine triphosphate (ATP) from the red blood cell (RBC) has been postulated as a mediator of peripheral vascular tone in response to shear stress, hypoxia, and mechanical ...
Brian S. Ferguson +5 more
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Red blood cell “aggregability”
Clinical Hemorheology and Microcirculation, 2009It is well understood that the extent of red blood cell (RBC) aggregation is determined by both plasmatic and cellular factors [10]. It is also clear that alterations of plasmatic and cellular factors may be related to separate disease processes [1]. For example, plasma composition may change (e.g., fibrinogen concentration increase) due to an acute ...
Oguz K, Baskurt, Herbert J, Meiselman
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Clinics in Laboratory Medicine, 2021
Red blood cell (RBC) transfusions are necessary to increase a patient's oxygen carrying capacity. The optimal transfusion trigger remains elusive, but a restrictive transfusion trigger of 7 g/dL has been shown in studies to reduce RBC transfusions without adversely affecting patient outcomes.
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Red blood cell (RBC) transfusions are necessary to increase a patient's oxygen carrying capacity. The optimal transfusion trigger remains elusive, but a restrictive transfusion trigger of 7 g/dL has been shown in studies to reduce RBC transfusions without adversely affecting patient outcomes.
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Transfusion Clinique et Biologique, 2010
Since its discovery in the 17th century, the red blood cell, recognized in time as the critical cell component for survival, has been the focus of much attention. Its unique role in gas exchange (oxygen/CO(2) transport) and its distinct characteristics (absence of nucleus; biconcave cell shape) together with an - in essence - unlimited supply lead to ...
Pasini, E., Mann, M., Thomas, A.
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Since its discovery in the 17th century, the red blood cell, recognized in time as the critical cell component for survival, has been the focus of much attention. Its unique role in gas exchange (oxygen/CO(2) transport) and its distinct characteristics (absence of nucleus; biconcave cell shape) together with an - in essence - unlimited supply lead to ...
Pasini, E., Mann, M., Thomas, A.
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The International Journal of Biochemistry & Cell Biology, 2002
Red blood cells are derived from haemopoietic stem cells in bone marrow. Following a series of maturation steps, directed largely by the hormone erythropoietin (Epo), red cells enucleate and enter the circulatory system. In circulation these small, flexible biconcave cells containing haemoglobin transport O(2) from the lungs to the periphery, and CO(2)
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Red blood cells are derived from haemopoietic stem cells in bone marrow. Following a series of maturation steps, directed largely by the hormone erythropoietin (Epo), red cells enucleate and enter the circulatory system. In circulation these small, flexible biconcave cells containing haemoglobin transport O(2) from the lungs to the periphery, and CO(2)
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Artificial Cells, Blood Substitutes, and Biotechnology, 1998
Soluble polymerized haemoglobin (polyhaemoglobin) is now in a phase III clinical trials. Patients have received up to 20 units (10 litres) in trauma surgery and other surgery. Polyhaemoglobin can be stored for more than 1 year. Haemoglobin solutions have no blood group antigen and can be used as a 'universal donor' oxygen carrier.
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Soluble polymerized haemoglobin (polyhaemoglobin) is now in a phase III clinical trials. Patients have received up to 20 units (10 litres) in trauma surgery and other surgery. Polyhaemoglobin can be stored for more than 1 year. Haemoglobin solutions have no blood group antigen and can be used as a 'universal donor' oxygen carrier.
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Cryopreservation of red blood cells
Vox Sanguinis, 1994“There is practically no mention in the literature of attempts to keep red blood cells alive in vitro, yet methods for their preservation might have much practical importance, and certainly would possess theoretical interest. Kept cells could be utilized for serum reactions or for transfusion.
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