Results 101 to 110 of about 60,471 (306)

Revisiting the Activity–Rotation Relation for Evolved Stars

The Astrophysical Journal
The magnetic dynamo mechanism of giant stars remains an open question, which can be explored by investigating their activity–rotation relations with multiple proxies. By using the data from the LAMOST and Galaxy Evolution Explorer surveys, we carried out
Henggeng Han, Song Wang, Xue Li, Chuanjie Zheng, Jifeng Liu   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Mixed-mode coupling in the red clump

Astronomy & Astrophysics
The investigation of global, resonant oscillation modes in red giant stars offers valuable insights into their internal structures. In this study, we investigate in detail the information we can recover on the structural properties of core-helium burning (CHeB) stars by examining how the coupling between gravity- and pressure-mode cavities depends on ...
van Rossem, Walter, Miglio, Andrea, Montalbán, Josefina   +2 more
openaire   +4 more sources

Metallicity of the Double Red Clump in the Milky Way Bulge

The Astrophysical Journal
We present a reanalysis of the metallicity of the double red clump (RC) stars from the Milky Way bulge. Two leading explanations for the existence of the double RC concern possible differences in chemical composition (multiple populations of stars) or ...
Zofia Budzik, Matylda Łukaszewicz, Radosław Poleski   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Li Evolution among Stars of Low/Intermediate Mass: the Metal-deficient Open Cluster NGC 2204

The Astronomical Journal
We have analyzed high-dispersion spectra in the Li 6708 Å region for 167 stars within the anticenter cluster NGC 2204. From 105 probable members, abundance analysis of 45 evolved stars produces [Fe/H] = −0.40 ± 0.12, [Si/Fe] = 0.14 ± 0.12, [Ca/Fe] = 0.29
Barbara J. Anthony-Twarog, Constantine P. Deliyannis, Aaron Steinhauer, Qinghui Sun, Bruce A. Twarog   +4 more
doaj   +1 more source

Stellar Ages of TESS Stars, Adopting Spectroscopic Data from Gaia GSP-Spec

Galaxies
The Gaia DR3 GSP-spec/TESS (GST) catalog combines asteroseismic data from NASA’s TESS mission with spectroscopic data from ESA’s Gaia mission, and contains about 116,000 Red Clump and Red Giant Branch stars, surpassing previous datasets in size and ...
Elisa Denis, Patrick de Laverny, Andrea Miglio, Alejandra Recio-Blanco, Pedro Alonso Palicio, Josefina Montalban, Carlos Abia   +6 more
doaj   +1 more source

Rotation in sdB stars as revealed by stellar oscillations

Open Astronomy, 2018
An interesting opportunity offered by the detection of stellar oscillations is the possibility to infer the internal rotation rate of a star through the so-called rotational splittings. Such seismic measurements remained rather scarce for hot B subdwarf (
Charpinet Stephane, Giammichele Noemi, Zong Weikai, Van Grootel Valérie, Brassard Pierre, Fontaine Gilles   +5 more
doaj   +1 more source