Results 111 to 120 of about 60,471 (306)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
The Astrophysical JournalRecently discovered massive α -enriched (MAE) stars have surface chemistry consistent with members of the older, thick-disk Milky Way population but high masses (∼1.5–3 M _⊙ ) that suggest these stars are young.
Zachary G. Maas +4 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Tracking the Evolution of Lithium in Giants Using Asteroseismology: Super-Li-rich Stars Are Almost Exclusively Young Red-clump Stars [PDF]
, 2021 Raghubar Singh +4 more
openalex +1 more source
The Astrophysical Journal LettersDetermining the evolutionary stage of stars is crucial for understanding the evolution of exoplanetary systems. In this context, red giant branch (RGB) and red clump (RC) stars, which formed at stages in the later evolution of stars situated before and ...
Wen-Xu Lin, Sheng-Bang Qian, Li-Ying Zhu
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Red clump distances to the inner Galactic structures
, 2005 The least well known structure of the Galaxy is its central region, because of the high extinction, the crowding and the confusion between disk and bulge sources along the line of sight. We show how the structure of the inner Galaxy and the dust distribution can be strongly constrained by using red clump stars as distance indicator. The results of this
Babusiaux, C., Gilmore, G.
openaire +2 more sources
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source