Results 121 to 130 of about 28,801 (234)

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

open access: yesAdvanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen   +7 more
wiley   +1 more source

Validation of "Clinical Red Flags" for RA-ILD in an Italian cohort. [PDF]

open access: yesFront Med (Lausanne)
Cela E   +10 more
europepmc   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

open access: yesAdvanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka   +4 more
wiley   +1 more source

The Red Flags of Potential Workplace Violence

open access: yes
In this episode of The Security Podcasts featuring Alan Saquella, Assistant Professor at the College of Business, Security and Intelligence at Embry-Riddle Aeronautical University, we discuss the red flags that a workplace violence incident may be about ...
Saquella, Alan
core  

Looking Beyond Red Flags

open access: yes, 2016
The presentation will look beyond red flags to inform Rx legitimacy judgments and subsequent prescribing and dispensing decisions. The presenter will describe the outcomes of two research projects that examined prescribers’ and pharmacists’ perceptions ...
Hagemeier, Nicholas E.
core  

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

open access: yesAdvanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang   +10 more
wiley   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

open access: yesAdvanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang   +8 more
wiley   +1 more source

Argo Delphi consensus statement on red flags and clinical gateways towards rare disease diagnosis. [PDF]

open access: yesSci Rep
Limongelli G   +18 more
europepmc   +1 more source

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