Results 151 to 160 of about 1,925,617 (316)

Modernizing governance: leadership, red flags, trust and professional power [PDF]

, 2013
Hard copies of the report can be ordered through the CIPFA Shop: http://secure.cipfa.org.uk/cgi-bin/CIPFA.storefront/EN/product ...
Hutton, William L., Massey, Andrew
core  

The AMBRE Project: Stellar parameterisation of the ESO:FEROS archived spectra

, 2012
The AMBRE Project is a collaboration between the European Southern Observatory (ESO) and the Observatoire de la Cote d'Azur (OCA) that has been established in order to carry out the determination of stellar atmospheric parameters for the archived spectra
A. Bijaoui, A. Recio-Blanco, Allen de Prieto, Allen de Prieto, Alonso, Alonso, Alvarez, Bagnulo, Bensby, Blackwell, Brault, C. C. Worley, C. Ordenovic, Crifo, di Benedetto, Fuhrmann, Fuhrmann, Fuhrmann, Fuhrmann, Fuhrmann, Fuhrmann, Gazzano, González Hernández, Gratton, Gratton, Gratton, Gratton, Gustafsson, Hekker, Kaufer, Kordopatis, Kovtyukh, Kovtyukh, Kovtyukh, Kupka, Kurucz, Luck, Luck, Luck, Luck, Majewski, Masana, Mayor, McWilliam, Melo, Mishenina, Mishenina, Mishenina, Mishenina, Mishenina, P. de Laverny, Palacios, Pasquini, Ramírez, Ramírez, Recio-Blanco, Soubiran, Steinmetz, Tonry, V. Hill, Valenti, Yanny   +61 more
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

Data Mining the SDSS SkyServer Database

, 2002
An earlier paper (Szalay et. al. "Designing and Mining MultiTerabyte Astronomy Archives: The Sloan Digital Sky Survey," ACM SIGMOD 2000) described the Sloan Digital Sky Survey's (SDSS) data management needs by defining twenty database queries and twelve ...
Gray, Jim, Kunszt, Peter Z., Slutz, Don, Stoughton, Christopher, Szalay, Alex S., Thakar, Ani R., vandenBerg, Jan   +6 more
core  

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Persepsi Auditor atas Tingkat Efektivitas Red Flags untuk Mendeteksi Kecurangan

Jurnal Akuntansi Multiparadigma, 2014
The research aims to identify auditors perception of red flags effectiveness in fraud detecting and examine the influence of auditor demographic factorssuch as characteristics (gender, job position, auditor tenure), and competence (education, fraud ...
Ni Wayan Rustiarini, Ni Luh Gde Novitasari   +1 more
doaj  

Diagnostic pathway for cardiac amyloidosis from the healthcare professional’s perspective: results from the French DIAM-ATTR survey

Annals of Medicine
Background Diagnosis of cardiac amyloidosis (CA) is complex and implicates several medical specialists. CA is usually suspected based on symptoms (‘red flags’) and non-invasive imagery.
Silvia Oghina, Damien Legallois, Fabien Hyafil, Walid Amara, Emmanuel Andrès, Thomas Bardin, Pauline Fournier, Sandra Guignard, Céline Labeyrie, Nicolas Piriou, Olivier Toulza, Romain Tresorier, Giorgia Canali, Margaux Dubois, Benoit Bouquillon, Cédric Sauvage, Pierre Sabouret, Philippe Charron, Thibaud Damy   +18 more
doaj   +1 more source