Results 191 to 200 of about 1,925,617 (316)

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Validation of "Clinical Red Flags" for RA-ILD in an Italian cohort. [PDF]

Front Med (Lausanne)
Cela E, Bonini C, Cavalli F, Luciano A, Kroegler B, Ora J, Bergamini A, Chiocchi M, Rogliani P, Chimenti MS, Conigliaro P.   +10 more
europepmc   +1 more source

TGFβ1 Activates Lnc‐APUE to Promote Tumor Metastasis via the Alu Element‐Driven STAU1‐Mediated Decay of CDH1 mRNA

Advanced Science, EarlyView.
We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li, Jia‐Hui Huang, Jin‐E Yang, Yi‐Hang Li, Juan‐Zhen Hong, Ting‐Ting Wang, Ying‐Lei Chi, Meng‐Zhi Wu, Wei Wang, Ying Zhu, Shi‐Mei Zhuang   +10 more
wiley   +1 more source

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source

Argo Delphi consensus statement on red flags and clinical gateways towards rare disease diagnosis. [PDF]

Sci Rep
Limongelli G, De Iaco F, Mosca M, Pecchia L, Piccinocchi G, Sangiorgi L, Scarpa M, Cafiero D, Politi L, Tedone F, Forte A, Caiazza M, De Stasio C, Fusco A, Morgillo B, Scala I, Scopinaro A, Facchin P, Argo Working Group.   +18 more
europepmc   +1 more source

Red Flag Investigations [PDF]

, 2013
Early project-level environmental analysis can save time and money. A Red Flag Analysis reveals possible environmental issues prior to the start of the design process and adds greater certainty to the design and budgeting process. The analysis can be done as part of the long-range transportation plan or at the pre-design project level.
openaire  

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

A paediatric patient with PRAKG2 cardiomyopathy: Look at the red flags. [PDF]

Eur Heart J Case Rep
Bello AR, Franco-Machado J, Carmo Mendes I, Rocha BML.   +3 more
europepmc   +1 more source

Symptoms and early-onset colorectal cancer: red flags are common flags! [PDF]

J Natl Cancer Inst, 2023
Yen T, Patel SG.
europepmc   +1 more source

Essence, Effects of Shadow Economy and Red Flags to Combat it in Ukraine [PDF]

, 2017
Yefimenko, Kateryna
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