Results 41 to 50 of about 3,595,170 (264)

Relevância dos red flags na detecção do risco de fraudes nas demonstrações contábeis: a percepção de auditores independentes brasileiros [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico. Programa de Pós-Graduação em ContabilidadeEsta dissertação de mestrado objetiva identificar a percepção de auditores independentes Brasileiros sobre a relevância dos
Murcia, Fernando Dal-Ri
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Análise do conhecimento dos discentes de Ciências Contábeis acerca dos red flags no processo investigativo da fraude [PDF]

, 2019
Artigo AcadêmicoNão possuiOs sinalizadores de fraudes, red flags, são meios que podem ser usados pelos profissionais de auditoria e perícia que na contabilidade são os que têm capacidade técnica para identificar ambientes fraudulentos. Nesse sentido, a
Costa, Meire Regina Oliveira
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Addressing CSR Red Flags as a Strategic Response to Economic Policy Uncertainty [PDF]

This study investigates whether companies strategically address corporate social responsibility (CSR) red flags to minimise their risks during periods of high economic policy uncertainty (EPU).
Dai, Yunhao, Yao, Daifei Troy, Tan, Weiqiang   +2 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Why this is not multiple sclerosis: a case based approach

Arquivos de Neuro-Psiquiatria, 2015
Objective To present a case series of patients previously diagnosed as multiple sclerosis (MS) which were later confirmed as an alternative diagnosis, and describe the clinical and paraclinical signs that led to this change.Method Nine patients are ...
Zaira Fernanda Martinho Nicolau, Enedina Maria Lobato de Oliveira, Denis Bernardi Bichuetti   +2 more
doaj   +1 more source

Análise do conhecimento dos discentes de ciências contábeis acerca dos red flags no processo investigativo da fraude

Revista Ambiente Contábil, 2023
Objetivo: A presente pesquisa tem por objetivo analisar as percepções dos discentes de Ciências Contábeis, das universidades públicas da cidade de Mossoró/RN, sobre os red flags no processo investigativo de fraude contábil.
Meire Regina Oliveira Costa, Caritsa Scartaty Moreira, Jocykleber Meireles de Souza, Camilla Araújo Amaral Duarte   +3 more
doaj   +1 more source