Results 201 to 210 of about 553,662 (337)

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

open access: yesAdvanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li   +21 more
wiley   +1 more source

High Radiation Resistance in the Binary W‐Ta System Through Small V Additions: A New Paradigm for Nuclear Fusion Materials

open access: yesAdvanced Science, EarlyView.
Refractory high‐entropy alloys exhibit superior radiation tolerance, but face fabrication challenges due to complex compositions. It is demonstrated that reducing the number of alloying elements does not compromise radiation resistance in a novel W‐Ta‐V highly‐concentrated refractory alloy.
Matheus A. Tunes   +16 more
wiley   +1 more source

OcuPair, a Novel Photo‐crosslinkable PAMAM Dendrimer‐Hyaluronic Acid Hydrogel Bandage/Bioadhesive for Corneal Injuries and Temporary Corneal Repair

open access: yesAdvanced Science, EarlyView.
A schematic diagram showing the OcuPair adhesive hydrogel formulation loaded into the final delivery device and applied over the full‐thickness corneal wound in an in vivo rabbit model of corneal injury followed by in situ crosslinking to form a transparent hydrogel bandage sealing the wound.
Siva P. Kambhampati   +6 more
wiley   +1 more source

Structurally Defined Water‐Soluble Metallofullerene Derivatives towards Biomedical Applications

open access: yesAngewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023
A modular metallobuckytrio (MBT) platform provides a family of structurally defined, water‐soluble metallofullerene derivatives that can safely carry rare‐earth elements in tailorable molecules, showing promise in biomedicines including MRI contrast agents and photosensitizers. Abstract Endohedral metallofullerenes (EMFs) are excellent carriers of rare‐
Yanbang Li   +15 more
wiley   +1 more source

Machine Learning Approach to Characterize Ferromagnetic La0.7Sr0.3MnO3 Thin Films via Featurization of Surface Morphology

open access: yesAdvanced Science, EarlyView.
A machine‐learning approach is presented to characterize ferromagnetic LSMO thin films by featurizing their surface morphology. Through an ensemble model, the non‐linear correlations between surface morphology and the electric/magnetic properties of LSMO thin films are successfully captured.
Sanghyeok Ryou   +5 more
wiley   +1 more source

Finding the unusual red giant remnants of cataclysmic variable mergers

open access: yesThe Open Journal of Astrophysics
Mergers between helium white dwarfs and main-sequence stars are likely common, producing red giant-like remnants making up roughly a few percent of all low-mass ($\lesssim2M_\odot$) red giants.
Nicholas Z. Rui, Jim Fuller
doaj   +1 more source

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