Results 81 to 90 of about 5,284,284 (237)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

<i>Trimma charon</i>, a new species of pygmygoby (Teleostei, Gobiidae) from the Red Sea with a key to the Red Sea species of the genus. [PDF]

Zookeys
Peinemann VN, Bogorodsky SV, Tietbohl Talas MD, Berumen ML.   +3 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Metagenomic Insights Into Red Sea Biodiversity Across the Web of Life. [PDF]

Environ Microbiol
Laiolo E, Hempel CA, Abukabbos BA, Abunayyan OI, Alam I, Alamoudi T, Alkhaldi WA, Almubarak ZM, Alnashri HA, Alothman A, Alqahtani TH, Alshaikh KA, Alsulaimani M, Alturki SA, Alva Garcia JV, Alzahrani AH, Amin SA, Ardan AA, Arossa S, Baalkhuyur F, Bähr S, Barozzi A, Barreca F, Breavington J, Daraghmeh N, Dhillon M, Dix M, Dunn N, English K, Ezeta Watts MA, Frappi S, Havlik MN, Imam KA, Kamau A, Kateb HA, Lim KK, Liu W, Mann H, Marchese F, Martynova A, Menzies J, Moret A, Muniz-Barreto M, Nolan MKB, Odobel C, Ogieglo JM, Parry AJ, Pedraza-Pohlenz R, Pluma N, Qutub A, Rabaoui LJ, Re E, Rivera Rosas DE, Roch C, Rodrigue M, Tayib FW, Terraneo TI, Thomson J, Villela H, Vimercati S, Angulo-Preckler C, Frühe L, Klein SG, Mineta K, Schmidt-Roach S, Steckbauer A, Benzoni F, Daffonchio D, Fox MD, Johnson MD, Agusti S, Aranda M, Berumen M, Gao X, Gojobori T, Peixoto R, van der Zwan FM, Pieribone V, Qurban M, Duarte CM.   +79 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Diacarnusins A-F, nor-Terpene Endoperoxides of the Red Sea Sponge Diacarnus erythraeanus. [PDF]

J Nat Prod
Hasib Afana R, Raijman-Nagar L, Ilan M, Carmeli S.   +3 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Catalog of metagenome-assembled genomes of prokaryotic communities from the Red Sea hydrothermal vents. [PDF]

Microbiol Resour Announc
Schultz J, Altalhi S, Camargo AP, Kyrpides NC, Rosado AS.   +4 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source