Results 161 to 170 of about 5,746,488 (258)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The Red Shift in Estrogen Research: An Estrogen-Receptor Targeted <i>aza</i>-BODIPY-Estradiol Fluorescent Conjugate. [PDF]

Int J Mol Sci
Hlogyik T, Bózsity N, Börzsei R, Kovács B, Labos P, Hetényi C, Kiricsi M, Huliák I, Kele Z, Poór M, Erostyák J, Hunyadi A, Zupkó I, Mernyák E.   +13 more
europepmc   +1 more source

Pyrazole, Imidazole, and Isoindolone Dipyrrinone Analogues: pH-Dependent Fluorophores That Red-Shift Emission Frequencies in a Basic Solution. [PDF]

J Org Chem, 2019
Benson N, Suleiman O, Odoh SO, Woydziak ZR.   +3 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Understanding the Red Shift in the Absorption Spectrum of the FAD Cofactor in ClCry4 Protein. [PDF]

J Phys Chem B
Kretschmer K, Frederiksen A, Reinholdt P, Kongsted J, Solov'yov IA.   +4 more
europepmc   +1 more source

Discovery of carotenoid red-shift in endolithic cyanobacteria from the Atacama Desert. [PDF]

Sci Rep, 2017
Vítek P, Ascaso C, Artieda O, Casero MC, Wierzchos J.   +4 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Correction to "Does the Red Shift in UV-Vis Spectra Really Provide a Sensing Option for Detection of N-Nitrosamines Using Metalloporphyrins?" [PDF]

ACS Omega
Trampuž M, Žnidarič M, Gallou F, Časar Z.   +3 more
europepmc   +1 more source

Furan- and Thiophene-Based Auxochromes Red-shift Chlorin Absorptions and Enable Oxidative Chlorin Polymerizations. [PDF]

Chemistry, 2017
Xiong R, Bornhof AB, Arkhypchuk AI, Orthaber A, Borbas KE.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source