Results 141 to 150 of about 15,293,964 (305)

Participación social, preparación comunitaria e intervención en salud. Estudios de caso de Trabajo Social en Atención Primaria de salud en Andalucía [PDF]

open access: yes, 2012
El presente estudio tuvo como objetivo la evaluación de la relación entre el contexto comunitario y el contexto organizativo en la implementación de programas de Atención Primaria de Salud en Andalucía (APS).
Holgado Ramos, Daniel   +1 more
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

5a Reunión de la Red para la Reducción de la Pobreza y la Protección Social

open access: yes, 2013
Esta presentación fue comisionada por la Red de Reducción de la Pobreza y Protección Social del Diálogo Regional de Política para la 5a Reunión Hemisférica celebrada los días 22 y 23 de mayo de 2003.
Gobierno Bolivariano de Venezuela
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Tastant, una red social gastronómica

open access: yes, 2022
El objetivo de este trabajo es desarrollar una aplicación web para compartir información de carácter gastronómico entre un grupo de personas con intereses comunes. Esta aplicación permite interactuar a usuarios con intereses comunes. Los usuarios pertenecen a grupos y la información compartida en un grupo sólo es visible por los miembros del grupo.
openaire   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Group portrait in Red Cloud, Nebraska

open access: yes, 1885
A photograph of a group of Red Cloud, Nebraska, citizens. They are: back row left: Dave Kaley, Bess Seymour, P D Yeiser, Tom Ferris, Bert Cromwell, Anna Kaley, Ryland Yeiser; middle row left: Ed Hasford, Laird Wallace, Clara Becker; front row left ...
Bradbrook, Red Cloud, NE
core  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

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