Results 181 to 190 of about 3,297,358 (361)

Relatives, friends and patronage. Network, mobility and social reproduction in the bourgeoisie and oligarchy at the end of the Ancien Régime (Albacete, 1750-1808)

open access: yesStudia Historica: Historia Moderna, 2009
This work tries to analyze the social relations of four families belonging to the elite of power and to the middle class in a town in growth as like it is Albacete at the end of the Ancien Régime.
Cosme Jesús GÓMEZ CARRASCO
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Social network for guardians of transgender children and adolescents. [PDF]

open access: yesEpidemiol Serv Saude
Abreu PD   +9 more
europepmc   +1 more source

Red social de enfermedades raras

open access: yes, 2021
Los pacientes y los familiares con enfermedades raras necesitan estar conectados con otras personas en su misma situación. El problema es que este tipo de enfermedades tiene una incidencia muy baja (cientos o miles de personas en el mundo), lo que hace que no exista un sistema para unir a estas personas entre sí.
openaire   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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