Results 51 to 60 of about 407,327 (266)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Audiencias televisivas y líderes de opinión en Twitter. Caso de estudio: El Barco

open access: yesEstudios sobre el Mensaje Periodístico, 2013
Este artículo presenta los resultados de una medición de flujo de tweets y su análisis posterior. Seguimos los modelos de predicción política ya utilizados para las campañas electorales por investigadores y autores previos. Proponemos también un análisis
Luis Deltell Escolar   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Virtualización organizacional, Web semántica y redes sociales

open access: yesVisión Electrónica, 2012
La información ha estado presente en todas las comunidades y en todas las épocas; sin embargo, hoy la productividad y el poder tienen como base las tecnologías de gestión de la información, del conocimiento y de la comunicación de símbolos.
Carlos H. Caicedo E.
doaj  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Prácticas sociales de migrantes en tránsito: teoría de la Práctica de Bourdieu

open access: yesEntreciencias: Diálogos en la Sociedad del Conocimiento
Propósito: comprender la práctica migratoria de personas migrantes con nacionalidad mexicana y extranjera que tienen el propósito de cruzar la frontera de México a Estados Unidos con el objetivo de analizar su posicionamiento frente a ese espacio social
Fernanda Guadalupe Rascón Arriaga   +2 more
doaj   +1 more source

Redes e Historias

open access: yesREDES: Revista Hispana para el Análisis de Redes Sociales, 2009
Este artículo esboza cómo el proceso social se lleva a cabo dentro, desde, y alrededor de redes de pares de relaciones. Estas relaciones se caracterizan por historias que se cuentan dentro y acerca de ellas, con significados que surgen de cambios entre ...
Harrison C. White
doaj   +1 more source

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