Results 51 to 60 of about 39,465 (276)
Advanced Science, EarlyView.A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu +13 more
wiley +1 more source
The Technological Factor: Redemption, Nature, and the Image of God
Zygon, 2000 This paper begins from the premise that being in the image of God refers humanity neither to nature nor to its technology but to God. Two positions are thereby rejected: (1) that nature should be treated as a source of salvation (Heidegger), and (2 ...
doaj +2 more sources
The Orthodox Doctrine of Salvation» by Archimandrite Sergius (Stragorodsky) and its criticism by Confessor of the Faith Victor (Ostrovidov) and Archbishop Seraphim (Sobolev) [PDF]
Вестник Православного Свято-Тихоновского гуманитарного университета: Серия ИИ. История, история Русской Православной Церкви, 2014 «The Orthodox Doctrine of Salvation», a well-known work by Archimandrite Sergius (Stragorodsky) that was defended by him as a master’s thesis at the Moscow Theological Academy in 1895, is still considered an etalon in Orthodox theology. Meanwhile, in the
P. KHONDSINSKIY
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Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche
Advanced Science, EarlyView.A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy +8 more
wiley +1 more source
EVOLUTIONARY THEODICY, REDEMPTION, AND TIME
Zygon, 2015 Of the many problems which evolutionary theodicy tries to address, the ones of animal suffering and extinction seem especially intractable. In this essay, I show how C. D.
doaj +2 more sources
Advanced Science, EarlyView.A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao +10 more
wiley +1 more source
Advanced Science, EarlyView.An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang +5 more
wiley +1 more source
Paedagogia Christiana, 2015 Artykuł dotyczy jednej z kluczowych doktryn chrześcijaństwa – usprawiedliwienia, która w okresie nowożytnym stało się teologicznym powodem podziału Kościoła na Zachodzie.
Piotr Kostyło
doaj +1 more source
Slave Redemption When it Takes Time to Redeem Slaves [PDF]
We analyze slave redemption programs—the buying of slaves to give them their freedom--in a simple matching model, i.e., under the assumption that it takes time to find slaves to buy or sell.
Kenneth A Swinnerton, Carol Ann Rogers
core
Advanced Science, EarlyView.This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li +9 more
wiley +1 more source