Results 21 to 30 of about 88,416 (289)

Estudio y pruebas de campo de redes de sensores sin hilos [PDF]

, 2008
El principal objetivo de este trabajo es el desarrollo de unas pruebas de campo en diferentes escenarios. Es realizar medidas subterráneas con unos sensores adecuados a ello, y compararlas en estos diferentes medios.
Cobos Melià, Víctor
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Redes inalámbricas de sensores para detección temprana de incendios forestales

Revista Científica Ciencia y Tecnología, 2018
En el presente trabajo se implementa un sistema de detección de incendios forestales denominado Forest Fire System, en el que se aplica redes de sensores inalámbricos (WSN).
Byron Oviedo, Emilio Zhuma Mera, Ángel Torres Quijije, María Vicuña Gaibor, Cinthia Solís López   +4 more
doaj   +1 more source

Planificación S-TDMA en redes submarinas de comunicaciones inalámbricas [PDF]

, 2015
Las redes submarinas de sensores son de importancia en la vigilancia y monitorización del medio submarino. Si se desea que las redes sean inalámbricas y con un alcance superior a unos pocos metros, las comunicaciones han de ser acústicas.
Díaz del Río, Víctor, Fernández-Salas, Luís Miguel, Luque-Nieto, Miguel Ángel, Moreno-Roldán, José Miguel, Otero, Pablo, Poncela-Gonzalez, Javier   +5 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Sistemas embebidos y en red para el control de sistemas físicos. Estudio de redes inalámbricas de sensores. [PDF]

, 2008
En este informe se presenta un estudio sobre los sistemas embebidos y en red para sistemas físicos, a través de la revisión de la literatura disponible, específicamente enfocado en las redes de sensores inalámbricas.
Caballero Retamosa, Bruno, Haber Guerra, Rodolfo E.   +1 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source