Results 21 to 30 of about 88,644 (290)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Redes inalámbricas de sensores para detección temprana de incendios forestales

Revista Científica Ciencia y Tecnología, 2018
En el presente trabajo se implementa un sistema de detección de incendios forestales denominado Forest Fire System, en el que se aplica redes de sensores inalámbricos (WSN).
Byron Oviedo, Emilio Zhuma Mera, Ángel Torres Quijije, María Vicuña Gaibor, Cinthia Solís López   +4 more
doaj   +1 more source

Planificación S-TDMA en redes submarinas de comunicaciones inalámbricas [PDF]

, 2015
Las redes submarinas de sensores son de importancia en la vigilancia y monitorización del medio submarino. Si se desea que las redes sean inalámbricas y con un alcance superior a unos pocos metros, las comunicaciones han de ser acústicas.
Díaz del Río, Víctor, Fernández-Salas, Luís Miguel, Luque-Nieto, Miguel Ángel, Moreno-Roldán, José Miguel, Otero, Pablo, Poncela-Gonzalez, Javier   +5 more
core   +1 more source

Otimização e tolerância a falhas em uma rede de sensores sem fio. [PDF]

, 2020
Resumo. Este artigo apresenta uma proposta de solução para otimização e tolerância a falhas para uma Rede de Sensores Sem Fio, que são redes próprias para coletar dados em ambientes inóspitos, hostis, de difícil acesso ou de custo de infraestrutura ...
ARAUJO, E. V. de, FAGOTTO, E. A. de M., SANTOS, M. J. dos, YANO, I. H.   +3 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sistemas embebidos y en red para el control de sistemas físicos. Estudio de redes inalámbricas de sensores. [PDF]

, 2008
En este informe se presenta un estudio sobre los sistemas embebidos y en red para sistemas físicos, a través de la revisión de la literatura disponible, específicamente enfocado en las redes de sensores inalámbricas.
Caballero Retamosa, Bruno, Haber Guerra, Rodolfo E.   +1 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Seguridad para protocolos MAC cooperativos en redes de sensores inalámbricas [PDF]

, 2009
Las redes de sensores inalámbricas han emergido como la tecnología que nos permite optimizar aplicaciones tan importantes como el control de la contaminación, el regadio eficiente, efectivo o la monitorización continua de señales vitales del paciente y ...
Casabona Gómez, Daniel, Leiva Martín, Daniel   +1 more
core