Results 141 to 150 of about 10,180,971 (304)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A reduced basis for option pricing [PDF]

We introduce a reduced basis method for the efficient numerical solution of partial integro-differential equations which arise in option pricing theory.
Rama Cont, Olivier Pironneau, Nicolas Lantos   +2 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Distinct Associations of Age and CYP2D6 Genotype With Parent Venlafaxine Exposure and O-Demethylation in Japanese Psychiatric Patients. [PDF]

Neuropsychopharmacol Rep
Ishihara Y, Sasaki T, Asahi T, Ono Y, Sugisaki T, Hiramatsu R, Kawamata Y, Sugawara N, Yasui-Furukori N.   +8 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Roughness-dependent retention of a reduced rabies-virus model in a platinum nanochannel: a molecular dynamics study. [PDF]

Virus Res
Singh NSS, Satea M, Kadhum AJ, Mahariq I, Barzani HAH, Hussein BA, Jumaah MD, Taner M, Salahshour S, Rahimi A.   +9 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

How reduced are reduced relatives?

Linguistics in the Netherlands, 1998
Petra Sleeman, Els Verheugd
openaire   +3 more sources

Insufficient dietary intake and symptom burden are associated with early nutritional decline in hospitalized patients with cancer. [PDF]

Support Care Cancer
Soares CH, Maffini LF, Friedrich HJ, Faccin GS, Steemburgo T.   +4 more
europepmc   +1 more source