Results 171 to 180 of about 16,498,605 (322)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Extended treatment for venous thromboembolism: Is direct oral anticoagulant dose-reduction better for all? [PDF]

Hemasphere
Lauw MN, Middeldorp S, Carrier M.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Family protective service involvement and reduced infant cortical grey matter volume. [PDF]

Infant Ment Health J
Penner F, Ahtam B, Ou Y, Grant PE, Lyons-Ruth K.   +4 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Longitudinal 3D-DCE MRI Assessment of Placental Perfusion Under Reduced Uterine Perfusion Pressure in Pregnant Rats. [PDF]

NMR Biomed
Al Darwish FM, van Kammen CM, Terstappen F, Alles LK, Schiffelers RM, Lely AT, Strijkers GJ, Coolen BF.   +7 more
europepmc   +1 more source

Solovay reducibility implies S2a-reducibility

The original notion of Solovay reducibility was introduced by Robert M. Solovay (unpublished notes) in 1975 as a measure of relative randomness. The S2a-reducibility introduced by Xizhong Zheng and Robert Rettinger (DOI:10.1007/978-3-540-27798-9_39) in 2004 is a modification of Solovay reducibility suitable for computably approximable (c.a.) reals ...
openaire   +2 more sources

Rising CO2 and warming reduce global canopy demand for nitrogen

Ning Dong, I. Colin Prentice
openalex   +1 more source

Decision letter for "Ibandronate reduces the surface bone resorption of mandibular bone grafts. A randomized trial with internal controls"

, 2021

openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source