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Reduce efficacy, reduce side effects
Science, 2020Nociception The μ-opioid receptor is an important target for pain management, but serious side effects limit the use of drugs that target this G protein–coupled receptor, which signals through both G proteins and β-arrestins. G protein–biased agonists have been developed to promote pain relief without causing β-arrestin–associated side effects.
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Reduce costs by reducing power
Proceedings of the 38th annual ACM SIGUCCS fall conference: navigation and discovery, 2010Managers of public computing facilities are challenged with how to keep computers updated while also minimizing downtime. That is often solved by letting computers update automatically overnight while facilities are closed, or having staff on hand to apply updates manually.
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Reducing measles mortality, reducing child mortality
The Lancet, 2006Edward J, Hoekstra +3 more
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