Results 201 to 210 of about 281,062 (262)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Fenofibrate restores glutamatergic and dopaminergic homeostasis in the nucleus accumbens and reduces alcohol relapse in rats. [PDF]

Front Pharmacol
Isla E, Gutiérrez-Vega I, Quilaqueo ME, Herrera-Marschitz M, Quintanilla ME, Morales P, Pérez-Reytor D, Rivera-Meza M, Karahanian E.   +8 more
europepmc   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

The global epidemiology of alcohol-associated liver disease. [PDF]

Hepatol Commun
Danpanichkul P, Danpanichkul P, Idalsoaga F, Murray F, Arab JP, Díaz LA.   +5 more
europepmc   +1 more source

Pharmacological profile of nalmefene for reducing alcohol consumption

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019
openaire   +2 more sources

Alcohol Consumption During Pregnancy Among Women Aged 18-49 Years - United States, 2021-2024. [PDF]

MMWR Morb Mortal Wkly Rep
Thomas SA, Gosdin LK, Terplan M, Kim SY, Deputy NP.   +4 more
europepmc   +1 more source

The impact of psychosocial factors on secondary hyperparathyroidism and vitamin D deficiency in adults with congenital heart disease-the CHD-HYPER study. [PDF]

Front Nutr
Löffler F, Linhorst K, Garlichs JC, Leitolf H, Terkamp C, Silber-Peest AS, Bauersachs J, Kahl KG, Westhoff-Bleck M.   +8 more
europepmc   +1 more source

Chronic alcohol consumption disrupts the gut microbial and metabolic landscapes. [PDF]

Front Microbiol
Blanton MB, Napier EG, Keen KE, Stuart EV, Cinco IR, Hemati H, Bruntz RC, Wilson L, Barnes S, Khadka R, Grant KA, Messaoudi I.   +11 more
europepmc   +1 more source

Effect of cannabinol, tetrahydrocannabivarin and cannabidiol on voluntary alcohol consumption. [PDF]

Alcohol Alcohol
Poceviciute I, Arbaciauskas M, Buisas R, Ruksenas O, Vengeliene V.   +4 more
europepmc   +1 more source