Results 241 to 250 of about 5,822,949 (305)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Special Issue "Alcohol and Inflammation". [PDF]

Int J Mol Sci
Martín-González C, González-Reimers E.   +1 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Dietary, lifestyle, and environmental factors associated with ulcerative colitis: a systematic review and meta-analysis of observational studies. [PDF]

Front Nutr
Wang Y, Xie T, Liao Z, He S, Zhao Y, Li Y, Kong X, Sun P.   +7 more
europepmc   +1 more source

Non-Alcoholic and Low-Alcohol Beer: Regulatory Complexity, Market Expansion and Technical Bottlenecks in Biological and Physical Dealcoholisation. [PDF]

Foods
D'Andrea A, Licciardo F, Celi E, Carbone K.   +3 more
europepmc   +1 more source

Decoding the serotonin-alcohol crosstalk: the role of central serotonergic dysregulation in alcohol use disorder. [PDF]

Pharmacol Rep
Zaniewska M.
europepmc   +1 more source

Hepatic, oxidative, and immunological alterations in adults with concomitant Schistosoma mansoni infection and alcohol abuse in an endemic area of Cameroon. [PDF]

BMC Infect Dis
Yimgoua ES, Nkondo ET, Femoe UM, Fassi-Kadji JB, Kenfack MC, Feussom NG, Vázquez S, Tchuem Tchuente LA, Sotillo J, Jatsa HB.   +9 more
europepmc   +1 more source

Morphine and nicotine intake in high drinking in the dark mice is reduced by informatics-nominated and translationally relevant compounds. [PDF]

Front Psychiatry
Ginder DE, Palacios J, Stewart M, Jensen BE, Borrego MB, Tzab L, Ozburn AR.   +6 more
europepmc   +1 more source