Results 161 to 170 of about 60,987 (263)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

Soft‐Layered Composites with Wrinkling‐Activated Multi‐Linear Elastic Behavior, Stress Mitigation, and Enhanced Strain Energy Storage

open access: yesAdvanced Engineering Materials, EarlyView.
In this study, exciting new bi‐/multi‐linear elastic behavior of soft elastic composites that accompany the activation of wrinkling in the embedded interfacial layers is analyzed. The new features and performance of these composite materials, including dramatic enhancements in energy storage, can be tailored by the concentration of interfacial layers ...
Narges Kaynia   +2 more
wiley   +1 more source

Static and Dynamic Behavior of Novel Y‐Shaped Sandwich Beams Subjected to Compressive Loadings: Integration of Supervised Learning and Experimentation

open access: yesAdvanced Engineering Materials, EarlyView.
In this study, the mechanical response of Y‐shaped core sandwich beams under compressive loading is investigated, using deep feed‐forward neural networks (DFNNs) for predictive modeling. The DFNN model accurately captures stress–strain behavior, influenced by design parameters and loading rates.
Ali Khalvandi   +4 more
wiley   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

open access: yesAdvanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian   +4 more
wiley   +1 more source

Nanoparticle‐Coated X2CrNiMo17‐12‐2 Powder for Additive Manufacturing—Part II: Processability by Powder Bed Fusion of Metals Using a Laser Beam

open access: yesAdvanced Engineering Materials, EarlyView.
In this manuscript, the processability of X2CrNiMo17‐12‐2 powder coated with silicon carbide, silicon, and silicon nitride nanoparticles is investigated. The amount of nanoparticles varies from 0.25 to 1 vol%. By coating the powder feedstock material with nanoparticles, an enlargement of the process window and an increase in the build rate are achieved.
Nick Hantke   +5 more
wiley   +1 more source

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