Results 171 to 180 of about 1,397,164 (333)

Exploiting correlations across trials and behavioral sessions to improve neural decoding. [PDF]

Neuron
Zhang Y, Lyu H, Hurwitz C, Wang S, Findling C, Wang Y, Hubert F, International Brain Laboratory, Pouget A, Varol E, Paninski L.   +10 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Task status evaluation strategy for dynamic traffic police dispatching in accident response​. [PDF]

Sci Rep
Zhang M, Zhou J, Dong S.
europepmc   +1 more source

Integrative Multi-View Reduced-Rank Regression: Bridging Group-Sparse and Low-Rank Models [PDF]

, 2018
Gen Li, Xiaokang Liu, Kun Chen
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Combined effects of mesenchymal stromal cells and antibiotic therapy on Enterobacter ventilator-associated pneumonia in rabbits. [PDF]

Respir Res
Jacquier M, Laroye C, Bensoussan D, Nguyen S, Croisier D, Richard C, Boidot R, Masson D, Charles PE, Blot M.   +9 more
europepmc   +1 more source

Appendix C. A discussion of the reduced-rank multinomial logit model and CQO.

, 2016
Thomas W. Yee
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

L-Quebrachitol Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption in Ovariectomized Rat Model. [PDF]

Biomolecules
Rattajak P, Aroonkesorn A, Yodthong T, Issuriya A, Maskaew S, Smythe C, Wititsuwannakul R, Pitakpornpreecha T.   +7 more
europepmc   +1 more source

Bayesian Period‐Varying Poisson Modelling With Reduced‐Rank Regression [PDF]

Jieun Lee, Myungjin Kim, Yongku Kim, Seung Yeop Yang, Jun‐Yeong Lee, Semin Oh, Seongjun Byun, Young Ho Kim, Ye Eun Park   +8 more
openalex   +1 more source