Results 221 to 230 of about 1,397,164 (333)

Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling. [PDF]

Nat Commun
Hu Y, Chen W, Lan S, Ming C, Xu D, Li H, Xu H, Shi D, Liu W, Dai Z, Wang J, He Z, Xu W, Shao Z, Liu Y, Tian H, Tong W.   +16 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Estrogen modulates reward prediction errors and reinforcement learning. [PDF]

Nat Neurosci
Golden CEM, Martin AC, Kaur D, Mah A, Levy DH, Yamaguchi T, Lasek AW, Lin D, Aoki C, Constantinople CM.   +9 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Temperature variability projections remain uncertain after constraining them to best performing Large Ensembles of individual Climate Models. [PDF]

Nat Commun
Suarez-Gutierrez L, Maher N.
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Cholinergic modulation mediates attentional mechanism to enhance coherence between cortical layers in macaque V1 and V4. [PDF]

Sci Rep
Sajedin A, FallahTaherpazir M, Menhaj MB.   +2 more
europepmc   +1 more source

Bureaucratic behavior modeled by reduced-rank regression: The case of expenditures from the Soviet state budget

, 1998
John P. Burkett
openalex   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Short-term analysis of urban noise dynamics during covid-19 lockdown using a machine learning approach in Mashhad, Iran. [PDF]

Sci Rep
Ardalan RV, Mohammadi M, Bahadari MS, Mohammadi M, Moezzi SMM, Saloglu D.   +5 more
europepmc   +1 more source