Results 261 to 270 of about 1,397,164 (333)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Model selection criteria for reduced rank multivariate time series with application in identification of periodic components

, 2011
Marcin Hławka, Maciej Kawecki
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Intratumor heterogeneity score reveals immune landscape and survival stratification in colorectal cancer. [PDF]

Front Immunol
Wang Z, Ma L, Cao J, Chen X, Chang X, Ma R, Lv H, Zhang Z, Li H, Jiang T.   +9 more
europepmc   +1 more source

Proximal guided hybrid federated learning approach with parameter efficient adaptive intelligence for pneumonia diagnosis. [PDF]

Sci Rep
P K, P S, Ar NK.
europepmc   +1 more source

Prediction of electricity consumption and hydropower production in the smart power grid based on the gated recurrent unit neural network and modified future search algorithm. [PDF]

Sci Rep
Tang H, Wang Y, Yuan X, Razmjooy N.
europepmc   +1 more source

Prevalence and prognostic implications of different aetiologies of low flow aortic stenosis. [PDF]

Cardiovasc Ultrasound
Fiore G, Biondi F, Fabris M, Cunsolo P, Morosato M, Gamardella M, Ingallina G, Stella S, Ancona F, Tavernese A, Margonato D, Belli M, Castiglioni A, Montorfano M, Maisano F, Agricola E.   +15 more
europepmc   +1 more source

Reduced Rank Multivariate Generalized Linear Models for Feature Extraction

, 2010
Yiyuan She
openalex   +1 more source