Results 141 to 150 of about 4,043,219 (290)
حول الحلقات الغامرة بضعف من النمط- np تقریباً
Al-Rafidain Journal of Computer Sciences and Mathematics, 2018 Raida D. Mahmood, Amaar M. Ghaze
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2016 Šī darba mērķis ir pētīt reducēto Rikarta gredzenu aksiomātiku, struktūru un dabisko (jeb Eibiena) sakārtojumu tajos. Rakstā [2] Rikarta gredzenos tika ieviestas fokālās operācijas.
Cremer, Insa Ingeborg Charlotte
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Al-Rafidain Journal of Computer Sciences and Mathematics, 2018 Nazar H. Shuker, Fryad H. Abdulqadir
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2016 Bu tezde indirgenmiş halka ve modüller, Baer ve quasi Baer halka ve modüller ile a-indirgenmiş modüller çalışılmıştır. Çalışma temel olarak dört bölümden oluşmaktadır. Ilk bölümde, teze giriş yapılmıştır.
Altun, Aslıhan
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Characterizing reduced Witt rings. II [PDF]
Pacific Journal of Mathematics, 1979 openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source