Results 181 to 190 of about 4,043,219 (290)

The Lord of the Rings: Cysteine bonds crosslink the tail of siphovirus. [PDF]

Protein Sci
Povilonienė S, Sasnauskas G, Tamulaitienė G, Labutytė G, Talaikis M, Mikšys A, Zajančkauskaitė A, Truncaitė L, Meškys R, Časaitė V.   +9 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Pediatric NIH Workshop: Session I: Nonhuman Primate Models in HIV Prevention Research-A Historical and Comparative Perspective. [PDF]

J Med Primatol
Van Rompay KKA, De Paris K, Veazey RS.
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Losing legs to facilitate sex: <i>Triramidesmus</i> gen. nov., a new remarkable monospecific genus of the millipede family Polydesmidae (Diplopoda, Polydesmida) from the Altai Mountains of northeastern Kazakhstan. [PDF]

Zookeys
Nefediev PS, Golovatch SI, Nefedieva JS.
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Synthesis of a Janus pentiptycene containing two thiophene rings using an intramolecular Fagan-Nugent reaction.

Chem Commun (Camb)
Montanaro S, Melvin RL, Elsegood MRJ, Wright IA.   +3 more
europepmc   +1 more source

Overlapping type 2, barrier, and remodeling endotypes shape clinical expression in eosinophilic esophagitis. [PDF]

Front Immunol
Wawrzeńczyk A, Napiórkowska-Baran K, Tykwińska M, Szota M, Bartuzi Z, Sławatycki J, Kanikowska A, Pałgan K.   +7 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Critical Tracheal Compression by a Double Aortic Arch in a Young Infant: A Case Report. [PDF]

Cureus
Molatedi K, Amod M, Kotze J, Swartbooi A.   +3 more
europepmc   +1 more source