Results 101 to 110 of about 4,904 (198)

Unveiling active sites and the cooperative role of non-thermal plasma and copper-zinc catalysts in the hydrogenation of CO₂ to methanol. [PDF]

Nat Catal
Xu S, Potter ME, Simancas R, Costley-Wood L, Qiu B, Liu X, Stere C, Molina MA, Farooq D, Tuna F, Zhang D, Zhang S, Chen H, Ding S, Wang X, Chansai S, Lindley M, Haigh SJ, Ibraliu A, Lan L, Chawdhury P, Bi M, Leahair O, Jiao Y, Hu M, Liu Q, Wakihara T, Fan X, Beale AM, Hardacre C.   +29 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The critical role of isolated Ti³⁺ sites in MIL-125 for photocatalytic nitrate reduction: performance enhancement and deactivation mechanism. [PDF]

Chem Sci
Liao L, Zhao G, Shu R, Wang X, Zhang J, Yuan R.   +5 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation. [PDF]

Redox Biol
Wang L, Zhong S, Fan X, Xu Y, Wang M, Xu Y, Cai Y, Cao Z, Ye Z, Wen L, Wei P.   +10 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

How reduced are reduced relatives?

Linguistics in the Netherlands, 1998
Petra Sleeman, Els Verheugd
openaire   +3 more sources

Unraveling surface sensitivity for generating metastable active sites in molybdenum-based catalysts for CO₂ hydrogenation. [PDF]

Nat Commun
Feng Y, Xing Z, Ye D, Niu J, Tian Y, Ma T, Cheng C, Yin B, Thomas A, Li S.   +9 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Polymorph-Induced Reducibility and Electron Trapping Energetics of Nb and W Dopants in TiO₂. [PDF]

J Phys Chem C Nanomater Interfaces
Chaudhari A, Logsdail AJ, Folli A.
europepmc   +1 more source