Results 171 to 180 of about 502,571 (335)

Emerging Strategies for Platelet‐Modified Nanoparticles in Targeted Tumor Therapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review highlights innovative strategies using platelet‐modified nanoparticles to target tumors more precisely. By mimicking platelet functions, these biomimetic carriers improve tumor homing, enhance drug delivery, and reduce immune clearance.
Chunyu Bai   +5 more
wiley   +1 more source

Engineered C–N Lyases for Stereoselective Synthesis of Tertiary Amines

open access: yesAngewandte Chemie, EarlyView.
EDDS lyase was subjected to iterative cycles of site‐saturation mutagenesis and screened for increased activity for the addition of 2‐((methylamino)methyl)aniline to fumarate. The final mutant, EDDS lyase CEA, accepts various N‐methyl‐1‐phenylmethanamines derivatives, yielding N,N‐disubstituted L‐aspartic acids, as well as several ortho‐substituted ...
Laura Bothof   +4 more
wiley   +2 more sources

Bioelectrosynthesis of Signaling Molecules for Selective Modulation of Cell Signaling

open access: yesAngewandte Chemie, EarlyView.
A bioelectrosynthesis platform is devised for electrochemical control of cellular signaling under physiological conditions. The system allows on‐demand, selective generation of signaling molecules, nitric oxide (NO) and ammonia (NH3), from nitrite (NO2−) ions using Cu2MoS4‐based electrocatalysts.
Myeongeun Lee   +6 more
wiley   +2 more sources

Hereditary Spherocytosis due to an SPTA1 Nonsense Mutation Coinherited With α spectrinLELY in Trans

open access: yes
American Journal of Hematology, EarlyView.
María‐Angustias Molina‐Arrebola   +1 more
wiley   +1 more source

Bicyclic Selenenyl Sulfides with Tuned Bioreductive Step Rates Reveal Constraints for Probes Targeting Thioredoxin Reductase

open access: yesAngewandte Chemie, EarlyView.
Thiol reductants activate dichalcogenide probes by a cascade of partly reversible steps. Careful dichalcogenide engineering can tune the rates of these steps separately, to aim at probes that are kinetically selective for specific oxidoreductases in live cells.
Lukas Zeisel   +6 more
wiley   +2 more sources

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