Results 201 to 210 of about 521,718 (340)

Regulation of gene expression and synthesis and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by micellar cholesterolin CaCo-2 cells.

Journal of Lipid Research, 1991
To investigate whether, and by what mechanisms, luminal (dietary) cholesterol regulates cholesterol synthesis in human intestinal cells, HMG-CoA reductase activity, gene expression, synthesis, and degradation were investigated in CaCo-2 cells exposed to ...
FJ Field, T Shreves, D Fujiwara, S Murthy, E Albright, SN Mathur   +5 more
doaj  

Association of Suicidality and Depression With 5&agr;-Reductase Inhibitors

JAMA Internal Medicine, 2017
B. Welk, E. McArthur, M. Ordon, K. Anderson, Jade S. Hayward, S. Dixon   +5 more
semanticscholar   +1 more source

Hydrogen Bond Assisted PCET and Formation of WIII‐OH in Bis‐dithiolene Complex

Angewandte Chemie International Edition, Accepted Article.
The redox non‐innocent nature of dithiolene ligands is well known for stabilizing high‐valent metal ions and facilitating proton‐coupled electron transfer (PCET) processes. Until now, proton reactivity at the dithiolene site has been primarily associated with low‐valent metal centers, as high‐valent metal‐dithiolene complexes were not considered viable
Wonjung Lee, Daeyong Um, Yujin Baek, Sugyeong Hong, Youngseob Lee, Jaeheon Lee, Jin Kim, Sun Hee Kim, Kyung-Bin Cho, Junhyeok Seo   +9 more
wiley   +1 more source

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Angewandte Chemie International Edition, Accepted Article.
These studies reveal the first structure of Clostridiumacetobutylicum alcohol dehydrogenase (CaADH), a protein exhibiting remarkable substrate promiscuity and stereochemical fidelity. The CaADH enzyme is utilized here for synthesizing 20 potential aryl isoserine side chains for the Taxotère family of tubulin‐binding chemotherapeutics.
Gaurav P. Kudalkar, Florian Leidner, Nivesh Kumar, Jared L. Hass, Peter Madzelan, Douglas R. Powell, Victor W. Day, Pierre Le Magueres, Joseph D. Ferrara, Lee M. Daniels, Akihito Yamano, Sho Ito, Wei Niu, Helmut Grubmueller, Mark A. Wilson, David B. Berkowitz   +15 more
wiley   +1 more source

Conversion of Reduced Nicotinamide-Adenine Dinucleotide Dehydrogenase into Reduced Nicotinamide-Adenine Dinucleotide-Ubiquinone Reductase [PDF]

, 1967
J.I. Salach, Thomas P. Singer, Peter Bader   +2 more
openalex   +1 more source

The Iron‐Sulfur Cluster of Bacterioferritin‐Associated Ferredoxin (Bfd): A ‘Biological Fuse’ that Prevents Oxidative Damage to Cells?

Angewandte Chemie International Edition, Accepted Article.
Iron is in an essential micronutrient in living systems. However, it is also potentially toxic and so the concentration of chelatable iron within cells is tightly regulated to prevent catalytic formation of harmful reactive oxygen species (ROS). Ferritins play a key role in iron homeostasis by storing excess iron as an insoluble ferric mineral within ...
Justin M. Bradley, Aiden M. Carter, Zinnia Bugg, Simon C. Andrews, Nick Le Brun   +4 more
wiley   +1 more source

STUDIES ON REDUCTASE

, 1915
David Fraser Harris, Henry Jermain Maude Creighton   +1 more
openalex   +1 more source

Purification and characterization of the flavoenzyme glutathione reductase from rat liver.

Journal of Biological Chemistry, 1975
I. Carlberg, B. Mannervik
semanticscholar   +1 more source

Optogenetic control of transgene expression in Marchantia polymorpha

Applications in Plant Sciences, EarlyView.
Abstract Premise The model liverwort Marchantia polymorpha is an emerging testbed species for plant metabolic engineering but lacks well‐characterized inducible promoters, which are necessary to minimize biochemical and physiological disruption when over‐accumulating target products.
Anya Lillemor Lindström Battle, Lee James Sweetlove   +1 more
wiley   +1 more source

Studies on Nitrate Reductase. I

, 1947
Fujio Egami, Ryo Sato
openalex   +2 more sources