Results 241 to 250 of about 502,571 (335)

Intricate Regulation of Sphingolipid Biosynthesis: An In‐Depth Look Into ORMDL‐Mediated Regulation of Serine Palmitoyltransferase

BioEssays, EarlyView.
Multiple enzymes play a crucial role in regulating the biosynthesis of de novo sphingolipids. This regulation starts with the rate‐limiting enzyme, serine palmitoyltransferase (SPT), which catalyzes the first step of the pathway. Disruptions in this regulatory process can lead to serious diseases.
Usha Mahawar, Binks Wattenberg
wiley   +1 more source

Cholic acid as a treatment for cerebrotendinous xanthomatosis: a comprehensive review of safety and efficacy. [PDF]

Orphanet J Rare Dis
Pasternack G, Courtney J, Kalsi G.
europepmc   +1 more source

Complex Interplay of Metabolic Substrates, Points of Entry into the Mitochondrial Electron Chain, and ROS Generation

BioEssays, EarlyView.
Recently, Singh et al. studied the influence of reactive oxygen species (ROS) formation by the ETC on mitochondrial morphology in baker's yeast. Their findings highlight evolutionary constraints, important trade‐offs using different metabolic substrates, and connections with points of entry into the ETC, ROS production, the FADH2/NADH ratio concept ...
Dave Speijer
wiley   +1 more source

Pharmacological Strategies for Cataract Management: From Molecular Targets to Clinical Translation. [PDF]

Int J Mol Sci
de Diego-García L, Rejas-González R, Latre IC, Guzman-Aranguez A.   +3 more
europepmc   +1 more source

The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis

BioEssays, EarlyView.
This review highlights the dynamic interplay between nitric oxide (NO) and reactive oxygen species (ROS) in regulating plant stem cell renewal and differentiation. NO and ROS integrate intrinsic factors like epigenetic and hormonal signals with extrinsic cues, including environmental stress and nutrient‐TOR signaling, to maintain meristem function and ...
Jian Zeng, Xin'Ai Zhao, Jan U. Lohmann
wiley   +1 more source

The iron metalloproteome of Pseudomonas aeruginosa under oxic and anoxic conditions. [PDF]

Metallomics
Saito MA, McIlvin MR.
europepmc   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Arbuscular mycorrhizal fungi enhance soil nutrient cycling by regulating soil bacterial community structures in mango orchards with different soil fertility rates. [PDF]

Front Microbiol
Han Y, Yuan G, Yang X, Fang L, Liang Y, Zhou B, Wei Z.   +6 more
europepmc   +1 more source

Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47

Cancer Communications, EarlyView.
Abstract Background Only a few bladder cancer patients benefit from anti‐programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immune evasion. CD47 is a highly glycosylated protein, however, the mechanisms governing CD47 glycosylation and its potential ...
Jie Zhang, Chen Zhang, Ruichen Zang, Weiwu Chen, Yining Guo, Haofei Jiang, Jing Le, Kunyu Wang, Haobo Fan, Xudong Wang, Sisi Mo, Peng Gao, Wenhao Guo, Xinrong Jiang, Fengbin Gao, Junming Jiang, Juyan Zheng, Yuxing Chen, Yicheng Chen, Yanlan Yu, Guoqing Ding   +20 more
wiley   +1 more source

Deciphering the biosynthesis pathway of gamma terpinene cuminaldehyde and para cymene in the fruit of Bunium persicum. [PDF]

Sci Rep
Samandari-Bahraseman MR, Hajibarati M, Khorsand B, Soltani N, Esmaeilzadeh-Salestani K, Loit E.   +5 more
europepmc   +1 more source