Results 241 to 250 of about 521,718 (340)

Biosynthesis of cholestanol: 5α-cholestan-3-one reductase of rat liver

open access: hybrid, 1966
Sarah Shefer   +2 more
openalex   +1 more source

Natural variation in arsenate tolerance identifies an arsenate reductase in Arabidopsis thaliana

open access: yesNature Communications, 2014
Eduardo Sanchez-Bermejo   +11 more
semanticscholar   +1 more source

Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

open access: yesChemBioChem, EarlyView.
Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Sophie R. Thomas, Riccardo Bonsignore
wiley   +1 more source

Shifting the Substrate Scope of an Ene/Yne‐Reductase by Loop Engineering

open access: yesChemCatChem, EarlyView.
A flexible active‐site loop that is involved in shaping the substrate and product cleft as well as the active‐site pocket was identified for the MDR‐related ene/yne‐reductase CaeEnR1 from Cyclocybe aegerita. Double mutations of this loop showed an up to 20‐fold increase in conversion rates toward cinnamaldehyde‐like substrates and a 2‐fold increase in ...
Dominik Karrer   +7 more
wiley   +1 more source

A Biocatalytic Cascade for the Valorization of Sugars

open access: yesChemCatChem, EarlyView.
We report a one‐pot, three‐step biocatalytic cascade to synthesize trihydroxy‐piperidine and ‐azepane iminosugars directly from monosaccharides, employing transaminase (ATA) and galactose oxidase (GOase) enzymes. Abstract Biocatalytic cascades offer products of multistep synthesis without the use of protecting groups or isolation of intermediates. This
Kathryn Yeow   +4 more
wiley   +1 more source

A Perspective on Process Design and Scale‐Up for Biocatalysis

open access: yesChemCatChem, EarlyView.
This perspective outlines the required steps to translate laboratory biocatalytic reactions into laboratory processes, with the required performance metrics prior to scaling for pilot testing. A range of tools are presented with the aim of using enzyme and process engineering synergistically.
John M. Woodley
wiley   +1 more source

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