Results 141 to 150 of about 13,343,923 (331)

Deep Learning Grid-point Temperature Forecasting in Changde City with Multi-scale Feature Integration

Gaoyuan qixiang
This study aims to enhance the accuracy of urban grid temperature forecasts by integrating multi-scale features from both upper-air and surface levels.Utilizing forecast data from the European Centre for Medium-Range Weather Forecasts （ECMWF） model and ...
Lu LI, Xiaoxiong YOU, Jingjing CHEN, Zhenju HU, Shu LU, Qiong LI   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Author Correction: Hurricane risk assessment in a multi-hazard context for Dominica in the Caribbean

Scientific Reports, 2023
Peter Sammonds, Akhtar Alam, Simon Day, Katerina Stavrianaki, Ilan Kelman   +4 more
doaj   +1 more source

Parametric design and numerical analysis of super long span upper-support thrust-bearing concrete arch bridge

Advances in Bridge Engineering
With the progress of construction technology and the application of high-performance materials, arch bridges are constantly breaking the span records. This study conducts parametric design and numerical analysis on upper-support thrust-bearing concrete ...
Yaojun Ge, Linqian Zheng, Zhuozhang Deng, Genshen Fang   +3 more
doaj   +1 more source

A Multi-step Nonlinear Dimension-reduction Approach with Applications to Bigdata

, 2018
R. Krishnan, V. A. Samaranayake, S. Jagannathan   +2 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Effect of surfactants on the size of iron particles formed by the reduction of ferrous ion in aqueous solution. Basic study to prepare the magnetic fluid using colloidal ferromagnetic metals.

, 1989
Toyohisa Fujita, Balachandran Jeyadevan, Mitsuo MAMIYA   +2 more
openalex   +2 more sources

Stratified Reduction of Singularities of Generalized Analytic Functions [PDF]

, 2022
Beatriz Molina-Samper, Jesús Palma-Márquez, F. Sanz-Sánchez   +2 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source